The title compound naphthalen-2-yl-4-methyl-1,2,3-thiadiazole-5-carboxylate （C 14 H 10 N 2 O 2 S,M r=270.31） was synthesized by the reaction of 4-methyl-1,2,3-thiadiazole-5-carbonyl chloride with 2-naphthol,and its ...The title compound naphthalen-2-yl-4-methyl-1,2,3-thiadiazole-5-carboxylate （C 14 H 10 N 2 O 2 S,M r=270.31） was synthesized by the reaction of 4-methyl-1,2,3-thiadiazole-5-carbonyl chloride with 2-naphthol,and its structure was characterized by IR,1 H NMR,high-resolution mass spectrometry and single-crystal X-ray diffraction.The crystal belongs to orthorhombic,space group Pbcn with a=23.475（5）,b=9.6640（19）,c=10.814（2）,β=90.00°,Z=8,V=2453.2（9） 3,M r=270.30,D c=1.464 g/cm 3,μ=0.262 mm-1,F（000）=1120,R=0.0444 and wR=0.1099.X-ray analysis revealed that the thiadiazole and naphthalene rings were non-planar,while the thiadiazole ring and the ester group were essentially planar,and two intermolecular hydrogen bonds C（6） H（6）···O（1） and C（14） H（14）···O（1） were observed.The preliminary biological test showed that the title compound had antifungal and antivirus activities against tobacco mosaic virus.展开更多
The title compound N-tert-butyl-N-（4-methyl-1,2,3-thiadiazole）-5-yl-N＇-（4-me-thyl-1,2,3-thiadiazole）-5-formyl-N＇-3,5-dichloropyrid-2-yl-diacylhydrazines （C18H17Cl2N7O3S2, Mr = 514.41） has been synthesized by t...The title compound N-tert-butyl-N-（4-methyl-1,2,3-thiadiazole）-5-yl-N＇-（4-me-thyl-1,2,3-thiadiazole）-5-formyl-N＇-3,5-dichloropyrid-2-yl-diacylhydrazines （C18H17Cl2N7O3S2, Mr = 514.41） has been synthesized by the reaction of N-tert-butyl-N＇-3,6-dichloropyridine-2-formyl hydrazine with 4-methyl-1,2,3-thiadiazole-5-carbonyl chloride and triethylamine, and its structure was characterized by 1H NMR, HR MS, and single-crystal X-ray diffraction. The crystal of the title compound belongs to monoclinic, space group C2/c with a = 27.726（8）, b = 11.045（3）, c = 14.507（4）A, β = 96.758（4）°, Z = 8, V = 4412（2） A^3, Dc = 1.549 g/cm^3, μ = 0.521 mm^-1, F（000） = 2112, R = 0.0405 and wR = 0.1153. X-ray analysis indicates that all rings are non-planar in this molecule. The bioassay results indicate that both the title compound and the positive control RH-5992 have weak fungicide activities, while the title compound has good insecticidal activity against Plutella xylostella L. and no insecticidal activity against Culex pipiens pallens.展开更多
基金Supported by the National Natural Science Foundation of China (Nos. 20872071 and 20911120069)the Natural Science Foundation of Tianjin (10JCZDJC17500)+2 种基金the National Key Project for Basic Research (2010CB126105)the Key Laboratory of Pesticide Chemistry and Application,Ministry of Agriculture (MOA) (No. MOAPCA200903)the Russian Foundation for Basic Research (grant numbers RFBR 08-03-00376 a and RFBR/NNSF 08-03-92208 a)
文摘The title compound naphthalen-2-yl-4-methyl-1,2,3-thiadiazole-5-carboxylate （C 14 H 10 N 2 O 2 S,M r=270.31） was synthesized by the reaction of 4-methyl-1,2,3-thiadiazole-5-carbonyl chloride with 2-naphthol,and its structure was characterized by IR,1 H NMR,high-resolution mass spectrometry and single-crystal X-ray diffraction.The crystal belongs to orthorhombic,space group Pbcn with a=23.475（5）,b=9.6640（19）,c=10.814（2）,β=90.00°,Z=8,V=2453.2（9） 3,M r=270.30,D c=1.464 g/cm 3,μ=0.262 mm-1,F（000）=1120,R=0.0444 and wR=0.1099.X-ray analysis revealed that the thiadiazole and naphthalene rings were non-planar,while the thiadiazole ring and the ester group were essentially planar,and two intermolecular hydrogen bonds C（6） H（6）···O（1） and C（14） H（14）···O（1） were observed.The preliminary biological test showed that the title compound had antifungal and antivirus activities against tobacco mosaic virus.
基金funded in part by the NNSFC (Nos. 20872071, 20672062 and 20911120069)the NSF of Tianjin (10JCZDJC17500)+3 种基金the National Key Project for Basic Research (2010CB126105)the Foundation of Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture (MOA) (No. MOAPCA200903)the Russian Foundation for Basic Research (grant numbers RFBR 08-03-00376a and RFBR/NNSF 08-03-92208a)the Foundation of Achievements Transformation and Spreading of Tianjin Agricultural Science and Technology (No. 201002250)
文摘The title compound N-tert-butyl-N-（4-methyl-1,2,3-thiadiazole）-5-yl-N＇-（4-me-thyl-1,2,3-thiadiazole）-5-formyl-N＇-3,5-dichloropyrid-2-yl-diacylhydrazines （C18H17Cl2N7O3S2, Mr = 514.41） has been synthesized by the reaction of N-tert-butyl-N＇-3,6-dichloropyridine-2-formyl hydrazine with 4-methyl-1,2,3-thiadiazole-5-carbonyl chloride and triethylamine, and its structure was characterized by 1H NMR, HR MS, and single-crystal X-ray diffraction. The crystal of the title compound belongs to monoclinic, space group C2/c with a = 27.726（8）, b = 11.045（3）, c = 14.507（4）A, β = 96.758（4）°, Z = 8, V = 4412（2） A^3, Dc = 1.549 g/cm^3, μ = 0.521 mm^-1, F（000） = 2112, R = 0.0405 and wR = 0.1153. X-ray analysis indicates that all rings are non-planar in this molecule. The bioassay results indicate that both the title compound and the positive control RH-5992 have weak fungicide activities, while the title compound has good insecticidal activity against Plutella xylostella L. and no insecticidal activity against Culex pipiens pallens.
