背景:玻璃酸钠本身特殊的理化性质决定了其非常重要的生理作用,如构成细胞基质、润滑关节、促进组织损伤修复等。目的:观察玻璃酸钠注射治疗不同病程髌骨软化症的疗效。方法:76例髌骨软化症患者关节腔内注射玻璃酸钠2 m L(以髌骨内侧缘...背景:玻璃酸钠本身特殊的理化性质决定了其非常重要的生理作用,如构成细胞基质、润滑关节、促进组织损伤修复等。目的:观察玻璃酸钠注射治疗不同病程髌骨软化症的疗效。方法:76例髌骨软化症患者关节腔内注射玻璃酸钠2 m L(以髌骨内侧缘为进针点,每周1次,5周为1个疗程),根据病程分两组,病程<3个月32例,病程>3个月44例,随访1年观察远期疗效。结果与结论:随访1年发现病程<3个月组的优良率达94%,远期疗效优于病程>3个月组(优良率73%)。治疗期间无明显毒副作用,其中有5例注射后疼痛加重,可能与髌下积液未抽尽和早期穿刺技术不熟练有关,休息后一两天均得到缓解,未发生感染。结果可见玻璃酸钠是治疗髌骨软化症的有效药物,早期治疗及合理的进针点是保证疗效的关键。展开更多
The Hodgkin–Huxley model assumes independent ion channel activation,although mutual interactions are common in biological systems.This raises the problem why neurons would favor independent over cooperative channel a...The Hodgkin–Huxley model assumes independent ion channel activation,although mutual interactions are common in biological systems.This raises the problem why neurons would favor independent over cooperative channel activation.In this study,we evaluate how cooperative activation of sodium channels affects the neuron’s information processing and energy consumption.Simulations of the stochastic Hodgkin–Huxley model with cooperative activation of sodium channels show that,while cooperative activation enhances neuronal information processing capacity,it greatly increases the neuron’s energy consumption.As a result,cooperative activation of sodium channel degrades the energy efficiency for neuronal information processing.This discovery improves our understanding of the design principles for neural systems,and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases.展开更多
为探究冻融循环下纳米黏土对滨海水泥土微观结构的改性效果,通过扫描电子显微镜微观测试对土体微观结构变化规律进行分析,探讨了土体的微观结构定量化参数与宏观力学特征的关联性。以纳米滨海水泥土为对象,利用扫描电子显微镜和Image Pr...为探究冻融循环下纳米黏土对滨海水泥土微观结构的改性效果,通过扫描电子显微镜微观测试对土体微观结构变化规律进行分析,探讨了土体的微观结构定量化参数与宏观力学特征的关联性。以纳米滨海水泥土为对象,利用扫描电子显微镜和Image Pro Plus软件获取土体在0、1、5、7、9、11次的冻融循环下的微观结构特征和量化参数。结果表明:①在未冻融的环境下,纳米黏土改善滨海水泥土微观结构效果明显,孔隙明显减小。②在冻融环境下,纳米黏土在冻融循环初期对滨海水泥土微观结构的改性效果好,表现在冻融循环0~5次内孔隙面积平均减少14.3%,而冻融循环7~11次时仅平均减少4.3%的孔隙面积。通过概率密度函数的分布可知纳米黏土抑制了滨海水泥土超大孔隙的发育。③纳米滨海水泥土的压缩系数对颗粒面积变化比较敏感,颗粒的数量、不均匀系数等微观结构参数对压缩系数的影响较小。展开更多
文摘背景:玻璃酸钠本身特殊的理化性质决定了其非常重要的生理作用,如构成细胞基质、润滑关节、促进组织损伤修复等。目的:观察玻璃酸钠注射治疗不同病程髌骨软化症的疗效。方法:76例髌骨软化症患者关节腔内注射玻璃酸钠2 m L(以髌骨内侧缘为进针点,每周1次,5周为1个疗程),根据病程分两组,病程<3个月32例,病程>3个月44例,随访1年观察远期疗效。结果与结论:随访1年发现病程<3个月组的优良率达94%,远期疗效优于病程>3个月组(优良率73%)。治疗期间无明显毒副作用,其中有5例注射后疼痛加重,可能与髌下积液未抽尽和早期穿刺技术不熟练有关,休息后一两天均得到缓解,未发生感染。结果可见玻璃酸钠是治疗髌骨软化症的有效药物,早期治疗及合理的进针点是保证疗效的关键。
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.lzujbky-2021-62)the Shanghai Municipal Science and Technology Major Project(Grant No.2018SHZDZX01)Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(LCNBI)and ZJLab,and the National Natural Science Foundation of China(Grant No.12247101).
文摘The Hodgkin–Huxley model assumes independent ion channel activation,although mutual interactions are common in biological systems.This raises the problem why neurons would favor independent over cooperative channel activation.In this study,we evaluate how cooperative activation of sodium channels affects the neuron’s information processing and energy consumption.Simulations of the stochastic Hodgkin–Huxley model with cooperative activation of sodium channels show that,while cooperative activation enhances neuronal information processing capacity,it greatly increases the neuron’s energy consumption.As a result,cooperative activation of sodium channel degrades the energy efficiency for neuronal information processing.This discovery improves our understanding of the design principles for neural systems,and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases.
文摘为探究冻融循环下纳米黏土对滨海水泥土微观结构的改性效果,通过扫描电子显微镜微观测试对土体微观结构变化规律进行分析,探讨了土体的微观结构定量化参数与宏观力学特征的关联性。以纳米滨海水泥土为对象,利用扫描电子显微镜和Image Pro Plus软件获取土体在0、1、5、7、9、11次的冻融循环下的微观结构特征和量化参数。结果表明:①在未冻融的环境下,纳米黏土改善滨海水泥土微观结构效果明显,孔隙明显减小。②在冻融环境下,纳米黏土在冻融循环初期对滨海水泥土微观结构的改性效果好,表现在冻融循环0~5次内孔隙面积平均减少14.3%,而冻融循环7~11次时仅平均减少4.3%的孔隙面积。通过概率密度函数的分布可知纳米黏土抑制了滨海水泥土超大孔隙的发育。③纳米滨海水泥土的压缩系数对颗粒面积变化比较敏感,颗粒的数量、不均匀系数等微观结构参数对压缩系数的影响较小。
