The effect of supersaturation, oxalate/calcium stoichiometrical ratio (Oxa2-/Ca2+) and ionic strength on the crystallization of calcium oxalate (CaOxa) was investigated in gel systems by a double diffusion technique. ...The effect of supersaturation, oxalate/calcium stoichiometrical ratio (Oxa2-/Ca2+) and ionic strength on the crystallization of calcium oxalate (CaOxa) was investigated in gel systems by a double diffusion technique. The supersaturation affects the morphology, phase composition, and aggregation of CaOxa crystals. To a certain con- centration, the effect of Oxa2- ions on the aggregation of calcium oxalate monohydrate (COM) was much stronger than that of Ca2+ ions. It indicated that the increase of the concentration of Oxa2- ions can more efficiently pro- mote the formation of CaOxa stones. The increase of ionic strength and the molar ratio of Ca2+/ Oxa2- also pro- motes the aggregation of COM crystals.展开更多
The animal models of calcium oxalate stones induced by hyperoxaluria, hypercalciuria and lack of vitamin were summaried, and effects of different inhibitors and Chinese traditional medicines on the formation of calcul...The animal models of calcium oxalate stones induced by hyperoxaluria, hypercalciuria and lack of vitamin were summaried, and effects of different inhibitors and Chinese traditional medicines on the formation of calculi in animals were discussed.展开更多
The effects of counterions of citric acid and EDTA on the crystallization of calcium oxalate(CaO x )were in-vestigated in silica gel with a doubl e diffusion technique.The ability o f inhibiting the growth and aggrega...The effects of counterions of citric acid and EDTA on the crystallization of calcium oxalate(CaO x )were in-vestigated in silica gel with a doubl e diffusion technique.The ability o f inhibiting the growth and aggregation of CaO x crystal and the ability of inducing f ormation of COD follows:potassium c itratesodium citrate >citric acid.Na 2 EDTA had a stronger ability to inhibi t the aggregation of CaO x crystals than that of EDTA,but a weak er ability to inhibit nucleation and growth of C aO x crystals.Since COM exhibits a greater degree of attachment to renal tubule cells in culture compared with COD,t hat is,COD is easy to be expelled from the body along with the urine.So both inducing formation of COD and in hibiting growth and aggregation of CaO x crystal can decrease the probability of urinary stones.These results hav e positive significance in the prevention and cure of urinary stones clin ically.展开更多
文摘The effect of supersaturation, oxalate/calcium stoichiometrical ratio (Oxa2-/Ca2+) and ionic strength on the crystallization of calcium oxalate (CaOxa) was investigated in gel systems by a double diffusion technique. The supersaturation affects the morphology, phase composition, and aggregation of CaOxa crystals. To a certain con- centration, the effect of Oxa2- ions on the aggregation of calcium oxalate monohydrate (COM) was much stronger than that of Ca2+ ions. It indicated that the increase of the concentration of Oxa2- ions can more efficiently pro- mote the formation of CaOxa stones. The increase of ionic strength and the molar ratio of Ca2+/ Oxa2- also pro- motes the aggregation of COM crystals.
文摘The animal models of calcium oxalate stones induced by hyperoxaluria, hypercalciuria and lack of vitamin were summaried, and effects of different inhibitors and Chinese traditional medicines on the formation of calculi in animals were discussed.
文摘The effects of counterions of citric acid and EDTA on the crystallization of calcium oxalate(CaO x )were in-vestigated in silica gel with a doubl e diffusion technique.The ability o f inhibiting the growth and aggregation of CaO x crystal and the ability of inducing f ormation of COD follows:potassium c itratesodium citrate >citric acid.Na 2 EDTA had a stronger ability to inhibi t the aggregation of CaO x crystals than that of EDTA,but a weak er ability to inhibit nucleation and growth of C aO x crystals.Since COM exhibits a greater degree of attachment to renal tubule cells in culture compared with COD,t hat is,COD is easy to be expelled from the body along with the urine.So both inducing formation of COD and in hibiting growth and aggregation of CaO x crystal can decrease the probability of urinary stones.These results hav e positive significance in the prevention and cure of urinary stones clin ically.
