Driven by a demand for better fuel economy and increasingly stringent emissions regulations over a wide range of customers and applications,engine manufacturers have turned towards engine downsizing as the most potent...Driven by a demand for better fuel economy and increasingly stringent emissions regulations over a wide range of customers and applications,engine manufacturers have turned towards engine downsizing as the most potent enabler to meet these requirements.With boosting systems becoming ever more numerous as the technical solutions to complex boosting requirements of the internal combustion engine increase,it is time for an overview of available and under development boosting technologies and systems and for a discussion of their relevance to downsizing efforts.The presented analysis shows that there are no standard solutions for all the different applications as the trends indicate a rising complexity to meet with the extreme boosting requirements predicted for the remainder of the decade.These trends include variable geometry,a shift from single to two(or more)stages,extensive actuation for bypassing exhaust flows,exhaust flow regulation and pulsating exhaust energy recovery, severe electrification and an extensive effort downstream from the turbine to capture waste heat after the principal turbo- charger/supercharger system.展开更多
In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and toler...In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib.展开更多
文摘Driven by a demand for better fuel economy and increasingly stringent emissions regulations over a wide range of customers and applications,engine manufacturers have turned towards engine downsizing as the most potent enabler to meet these requirements.With boosting systems becoming ever more numerous as the technical solutions to complex boosting requirements of the internal combustion engine increase,it is time for an overview of available and under development boosting technologies and systems and for a discussion of their relevance to downsizing efforts.The presented analysis shows that there are no standard solutions for all the different applications as the trends indicate a rising complexity to meet with the extreme boosting requirements predicted for the remainder of the decade.These trends include variable geometry,a shift from single to two(or more)stages,extensive actuation for bypassing exhaust flows,exhaust flow regulation and pulsating exhaust energy recovery, severe electrification and an extensive effort downstream from the turbine to capture waste heat after the principal turbo- charger/supercharger system.
文摘In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib.
