Xuefu Zhuyu decoction has been used for treating traumatic brain injury and improving post-traumatic dysfunction, but its mechanism of action needs further investigation. This study established rat models of traumatic...Xuefu Zhuyu decoction has been used for treating traumatic brain injury and improving post-traumatic dysfunction, but its mechanism of action needs further investigation. This study established rat models of traumatic brain injury by controlled cortical impact. Rat models were intragastrically administered 9 and 18 g/kg Xuefu Zhuyu decoction once a day for 14 or 21 days. Changes in neurological function were assessed by modified neurological severity scores and the Morris water maze. Immunohistochemistry, western blot assay, and re- verse-transcription polymerase chain reaction were used to analyze synapsin protein and mRNA expression at the injury site of rats. Our results showed that Xuefu Zhuyu decoction visibly improved neurological function of rats with traumatic brain injury. These changes were accompanied by increased expression of synaptophysin, synapsin I, and postsynaptic density protein-95 protein and mRNA in a dose-de- pendent manner. These findings indicate that Xuefu Zhuyu decoction increases synapsin expression and improves neurological deficits alder traumatic brain injury.展开更多
The nearly 30-year economic growth miracle brings the consequent tremendous poor-rich gap leading strong drives for social transformation in current China. Chinese top leaders have realized to increase the peoples＇ i...The nearly 30-year economic growth miracle brings the consequent tremendous poor-rich gap leading strong drives for social transformation in current China. Chinese top leaders have realized to increase the peoples＇ income, improve quality of life and construct a ＂harmonious society＂ as key missions especially in recent 10 years. How to measure a harmonious society is one important topic as different measures may lead to different development policies. This paper outlines over 10 indices relevant to measure a harmonious society. Some are global indicators, while some are contributed by domestic researchers and arouse debates. Most of those indicators require conducting surveys on social attitudes under micro levels, which is always time consuming with problem of data quality. As Internet technology advances provide ways to record and disseminate fresh community ideas and thoughts conveniently, detecting topics or emotions from on-line public opinions is becoming a trend or one supplement way to overcome those data acquisition problems. This paper discusses one approach to on-line societal risk perception using hot search words and BBS posts. Such a trial aims to provide another way to societal risk perception different from those in traditional socio psychology studies. Challenges are also indicated.展开更多
The commercial high-resolution imaging satellite with 1 m spatial resolution IKONOS is an important data source of information for urban planning and geographical information system (GIS) applications. In this paper, ...The commercial high-resolution imaging satellite with 1 m spatial resolution IKONOS is an important data source of information for urban planning and geographical information system (GIS) applications. In this paper, a morphological method is proposed. The proposed method combines the automatic thresholding and morphological operation techniques to extract the road centerline of the urban environment. This method intends to solve urban road centerline problems, vehicle, vegetation, building etc. Based on this morphological method, an object extractor is designed to extract road networks from highly remote sensing images. Some filters are applied in this experiment such as line reconstruction and region filling techniques to connect the disconnected road segments and remove the small redundant. Finally, the thinning algorithm is used to extract the road centerline. Experiments have been conducted on a high-resolution IKONOS and QuickBird images showing the efficiency of the proposed method.展开更多
The main objective of this study was to compare the results obtained with both virtual and experimental research methods, when the biomechanical behavior of teeth restored with esthetic posts was investigated. The fin...The main objective of this study was to compare the results obtained with both virtual and experimental research methods, when the biomechanical behavior of teeth restored with esthetic posts was investigated. The finite element method was used to develop models of healthy maxillary canines and maxillary canines restored with definitive crowns and glass-fiber posts, quartzfiber posts, and titanium posts. Stress distribution was observed when external loads were applied. Load was applied in-vitro to analyse the fracture resistance of 48 maxillary canines restored in the same way as it was considered in the virtual method. The analysis of results using the finite element method led to the conclusion that restored teeth, in which the elastic modulus of the post was similar to that of the dentine and the material of the core had the best biomechanical performance. The experimental study validated the virtual analysis.展开更多
基金supported by the National Natural Science Foundation of China,No.81673719,81173175 and 81303074a grant from China Postdoctoral Science Foundation,No.2016M600639 and 2017T100614
文摘Xuefu Zhuyu decoction has been used for treating traumatic brain injury and improving post-traumatic dysfunction, but its mechanism of action needs further investigation. This study established rat models of traumatic brain injury by controlled cortical impact. Rat models were intragastrically administered 9 and 18 g/kg Xuefu Zhuyu decoction once a day for 14 or 21 days. Changes in neurological function were assessed by modified neurological severity scores and the Morris water maze. Immunohistochemistry, western blot assay, and re- verse-transcription polymerase chain reaction were used to analyze synapsin protein and mRNA expression at the injury site of rats. Our results showed that Xuefu Zhuyu decoction visibly improved neurological function of rats with traumatic brain injury. These changes were accompanied by increased expression of synaptophysin, synapsin I, and postsynaptic density protein-95 protein and mRNA in a dose-de- pendent manner. These findings indicate that Xuefu Zhuyu decoction increases synapsin expression and improves neurological deficits alder traumatic brain injury.
基金supported by National Basic Research Program of China under Grant No.2010CB731405Natural Science Foundation of China under Grant No.71171187
文摘The nearly 30-year economic growth miracle brings the consequent tremendous poor-rich gap leading strong drives for social transformation in current China. Chinese top leaders have realized to increase the peoples＇ income, improve quality of life and construct a ＂harmonious society＂ as key missions especially in recent 10 years. How to measure a harmonious society is one important topic as different measures may lead to different development policies. This paper outlines over 10 indices relevant to measure a harmonious society. Some are global indicators, while some are contributed by domestic researchers and arouse debates. Most of those indicators require conducting surveys on social attitudes under micro levels, which is always time consuming with problem of data quality. As Internet technology advances provide ways to record and disseminate fresh community ideas and thoughts conveniently, detecting topics or emotions from on-line public opinions is becoming a trend or one supplement way to overcome those data acquisition problems. This paper discusses one approach to on-line societal risk perception using hot search words and BBS posts. Such a trial aims to provide another way to societal risk perception different from those in traditional socio psychology studies. Challenges are also indicated.
文摘The commercial high-resolution imaging satellite with 1 m spatial resolution IKONOS is an important data source of information for urban planning and geographical information system (GIS) applications. In this paper, a morphological method is proposed. The proposed method combines the automatic thresholding and morphological operation techniques to extract the road centerline of the urban environment. This method intends to solve urban road centerline problems, vehicle, vegetation, building etc. Based on this morphological method, an object extractor is designed to extract road networks from highly remote sensing images. Some filters are applied in this experiment such as line reconstruction and region filling techniques to connect the disconnected road segments and remove the small redundant. Finally, the thinning algorithm is used to extract the road centerline. Experiments have been conducted on a high-resolution IKONOS and QuickBird images showing the efficiency of the proposed method.
文摘The main objective of this study was to compare the results obtained with both virtual and experimental research methods, when the biomechanical behavior of teeth restored with esthetic posts was investigated. The finite element method was used to develop models of healthy maxillary canines and maxillary canines restored with definitive crowns and glass-fiber posts, quartzfiber posts, and titanium posts. Stress distribution was observed when external loads were applied. Load was applied in-vitro to analyse the fracture resistance of 48 maxillary canines restored in the same way as it was considered in the virtual method. The analysis of results using the finite element method led to the conclusion that restored teeth, in which the elastic modulus of the post was similar to that of the dentine and the material of the core had the best biomechanical performance. The experimental study validated the virtual analysis.
