目的观察盐酸法舒地尔注射液联合丁苯酞软胶囊治疗急性脑梗死14d的美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分改善及对血清基质金属蛋白酶2(matrix metalloproteinase-2,MMP-2)、基质金属蛋白酶...目的观察盐酸法舒地尔注射液联合丁苯酞软胶囊治疗急性脑梗死14d的美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分改善及对血清基质金属蛋白酶2(matrix metalloproteinase-2,MMP-2)、基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)表达水平的影响。方法将78例急性脑梗死患者随机分为观察组和对照组各39例。对照组采用常规对症治疗,观察组在对照组治疗基础上加用盐酸法舒地尔注射液静脉滴注和丁苯酞软胶囊口服,2组均连续治疗14d。分别于治疗前后采用NIHSS评分对2组进行神经功能测定,并对治疗前后MMP-2、MMP-9水平进行比较。结果经过14d的治疗,观察组总有效率优于对照组(P<0.05),2组NIHSS评分及血清MMP-2、MMP-9水平均较治疗前显著降低(P<0.05),但观察组降低幅度更大,治疗后观察组NIHSS评分及血清MMP-2、MMP-9水平均低于对照组,差异有统计学意义(P<0.05)。结论盐酸法舒地尔注射液联合丁苯酞软胶囊可降低急性脑梗死患者的NIHSS评分,显著下调血清中MMP-2、MMP-9的表达。其机制可能与抑制炎症反应、减轻卒中后继发性脑损伤有关。展开更多
MMP-9 is one of the family of matrix metalloproteinases, which degrades extracellular matrix. MMP-9 is induced by many inflammatory factors, including IL-1β,IL-8 and TNF-α. Meanwhile, MMP-9 potentiates inflammatory ...MMP-9 is one of the family of matrix metalloproteinases, which degrades extracellular matrix. MMP-9 is induced by many inflammatory factors, including IL-1β,IL-8 and TNF-α. Meanwhile, MMP-9 potentiates inflammatory factors by aminoterminal processing. The signal transduction by which inflammatory factors induce MMP-9 is also an important part in recent research. This review will give a summary in all these fields.展开更多
文摘目的观察盐酸法舒地尔注射液联合丁苯酞软胶囊治疗急性脑梗死14d的美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分改善及对血清基质金属蛋白酶2(matrix metalloproteinase-2,MMP-2)、基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)表达水平的影响。方法将78例急性脑梗死患者随机分为观察组和对照组各39例。对照组采用常规对症治疗,观察组在对照组治疗基础上加用盐酸法舒地尔注射液静脉滴注和丁苯酞软胶囊口服,2组均连续治疗14d。分别于治疗前后采用NIHSS评分对2组进行神经功能测定,并对治疗前后MMP-2、MMP-9水平进行比较。结果经过14d的治疗,观察组总有效率优于对照组(P<0.05),2组NIHSS评分及血清MMP-2、MMP-9水平均较治疗前显著降低(P<0.05),但观察组降低幅度更大,治疗后观察组NIHSS评分及血清MMP-2、MMP-9水平均低于对照组,差异有统计学意义(P<0.05)。结论盐酸法舒地尔注射液联合丁苯酞软胶囊可降低急性脑梗死患者的NIHSS评分,显著下调血清中MMP-2、MMP-9的表达。其机制可能与抑制炎症反应、减轻卒中后继发性脑损伤有关。
文摘MMP-9 is one of the family of matrix metalloproteinases, which degrades extracellular matrix. MMP-9 is induced by many inflammatory factors, including IL-1β,IL-8 and TNF-α. Meanwhile, MMP-9 potentiates inflammatory factors by aminoterminal processing. The signal transduction by which inflammatory factors induce MMP-9 is also an important part in recent research. This review will give a summary in all these fields.
