Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for u...Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix(ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.展开更多
目的评价踝关节镜下微骨折手术治疗距骨骨软骨损伤的疗效。方法回顾分析2005年7月至2012年8月瑞金医院骨科采用踝关节镜下微骨折方法治疗距骨骨软骨损伤的163例患者临床资料,其中男性79例,女性84例,年龄18～72（38.6±14.2）岁。分...目的评价踝关节镜下微骨折手术治疗距骨骨软骨损伤的疗效。方法回顾分析2005年7月至2012年8月瑞金医院骨科采用踝关节镜下微骨折方法治疗距骨骨软骨损伤的163例患者临床资料,其中男性79例,女性84例,年龄18～72（38.6±14.2）岁。分别采用疼痛视觉模拟评分（VAS）和美国足踝医师协会后足与踝关节评分（AOFAS HA score）对患者术前、术后12个月的疼痛情况和功能进行评价,部分患者在术后12个月随访时通过核磁共振影像对距骨软骨进行评价。结果 94例患者获得随访,随访时间（22.8±10.3）个月。VAS从术前的（4.51±0.84）分下降到术后的（0.98±0.90）分;AOFAS HA评分从术前的平均75分提高到术后的平均91分。25例患者记录了术后核磁共振影像,软骨修复情况均较术前影像有改善。结论踝关节镜下微骨折手术治疗距骨骨软骨损伤简单、安全,效果可靠、满意。展开更多
基金supported by NSFC (nos 61471168, 61571187,61301043,and 61527806)China Postdoctoral Science Foundation (2016T90403)the Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province [(2013)448]
文摘Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix(ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.
文摘目的评价踝关节镜下微骨折手术治疗距骨骨软骨损伤的疗效。方法回顾分析2005年7月至2012年8月瑞金医院骨科采用踝关节镜下微骨折方法治疗距骨骨软骨损伤的163例患者临床资料,其中男性79例,女性84例,年龄18～72（38.6±14.2）岁。分别采用疼痛视觉模拟评分（VAS）和美国足踝医师协会后足与踝关节评分（AOFAS HA score）对患者术前、术后12个月的疼痛情况和功能进行评价,部分患者在术后12个月随访时通过核磁共振影像对距骨软骨进行评价。结果 94例患者获得随访,随访时间（22.8±10.3）个月。VAS从术前的（4.51±0.84）分下降到术后的（0.98±0.90）分;AOFAS HA评分从术前的平均75分提高到术后的平均91分。25例患者记录了术后核磁共振影像,软骨修复情况均较术前影像有改善。结论踝关节镜下微骨折手术治疗距骨骨软骨损伤简单、安全,效果可靠、满意。
