通过熔融缩聚法成功合成了一种主链含5-氟尿嘧啶(5-FU)的可生物降解聚丁二酸丁二酯共聚物前药,采用红外分光光度法、核磁共振法和紫外分光光度法对共聚物结构进行了表征,并对共聚物的体外释药性能进行了初步试验。结果表明共聚物具有预...通过熔融缩聚法成功合成了一种主链含5-氟尿嘧啶(5-FU)的可生物降解聚丁二酸丁二酯共聚物前药,采用红外分光光度法、核磁共振法和紫外分光光度法对共聚物结构进行了表征,并对共聚物的体外释药性能进行了初步试验。结果表明共聚物具有预期的结构并具有体外释药性,共聚物在p H 1.7的缓冲液中120 h最大释药率为80.3%。共聚物具有良好的降解性能和释药性能,可作为一种新颖的可生物降解药物缓释材料。展开更多
The kinetics of I-->N transition of a side chain nematic polymethacrylate has been studied by small angle depolarized light scattering intensity measurements using a charge coupled device linear image sensor. The p...The kinetics of I-->N transition of a side chain nematic polymethacrylate has been studied by small angle depolarized light scattering intensity measurements using a charge coupled device linear image sensor. The polymer shows the transition temperatures K52N79I in degreesC, The H-v scattering intensity T(q,t) during the transition I (at 80.2degreesC)-->N (at 75.8degreesC) shows that T(q) is independent of q for all t, and during the initial stage (in 6 s) T(t) increases exponentially with t. In the later stage of the transition T(t) approaches a saturation value in 2 min. This experimental result indicates that the I-->N transition of a liquid crystalline polymer is a spinodal type of phase transition mediated by orientation fluctuation.展开更多
Based on the molecular design principle camphene derivatives - modified epoxy macromer withhigh UV absorption coefficients and low ionization Potentials were designed, synthesized and character-ized. UV copolymerizati...Based on the molecular design principle camphene derivatives - modified epoxy macromer withhigh UV absorption coefficients and low ionization Potentials were designed, synthesized and character-ized. UV copolymerization of macromer were carried out by the use of ethoxy benzoin and sulfoniumcomples|BDS (2PF6 )2-| under the designed conditions. Characterization of polymrization reactionand polmperized products have been done by means of IR, DSC, UV, microscope and poarizing microscopy, transmitancy and surface property measurment, as well as systematically determination ofpolmperization rate and shrinkage. The results have shown that the above - described macromers withoptimal proportion combination can efficiently absorb the light enefgy within 250 run to 365 nm andprovide not only high rate and low shrinknge of polymerization, but also good optical, wetting, adhesionand other physico - chemical properties without any oxygen inhibition innuence which can metthe spe-cial requirments of optical compo8ites for manufacturing of Multiplical Spherical Equation belensComplex.展开更多
文摘通过熔融缩聚法成功合成了一种主链含5-氟尿嘧啶(5-FU)的可生物降解聚丁二酸丁二酯共聚物前药,采用红外分光光度法、核磁共振法和紫外分光光度法对共聚物结构进行了表征,并对共聚物的体外释药性能进行了初步试验。结果表明共聚物具有预期的结构并具有体外释药性,共聚物在p H 1.7的缓冲液中120 h最大释药率为80.3%。共聚物具有良好的降解性能和释药性能,可作为一种新颖的可生物降解药物缓释材料。
基金This work was supported by the National Key Projects for Fundamental Research, "Macromolecular Condensed State" of Ministry of Science and Technology of China.
文摘The kinetics of I-->N transition of a side chain nematic polymethacrylate has been studied by small angle depolarized light scattering intensity measurements using a charge coupled device linear image sensor. The polymer shows the transition temperatures K52N79I in degreesC, The H-v scattering intensity T(q,t) during the transition I (at 80.2degreesC)-->N (at 75.8degreesC) shows that T(q) is independent of q for all t, and during the initial stage (in 6 s) T(t) increases exponentially with t. In the later stage of the transition T(t) approaches a saturation value in 2 min. This experimental result indicates that the I-->N transition of a liquid crystalline polymer is a spinodal type of phase transition mediated by orientation fluctuation.
文摘Based on the molecular design principle camphene derivatives - modified epoxy macromer withhigh UV absorption coefficients and low ionization Potentials were designed, synthesized and character-ized. UV copolymerization of macromer were carried out by the use of ethoxy benzoin and sulfoniumcomples|BDS (2PF6 )2-| under the designed conditions. Characterization of polymrization reactionand polmperized products have been done by means of IR, DSC, UV, microscope and poarizing microscopy, transmitancy and surface property measurment, as well as systematically determination ofpolmperization rate and shrinkage. The results have shown that the above - described macromers withoptimal proportion combination can efficiently absorb the light enefgy within 250 run to 365 nm andprovide not only high rate and low shrinknge of polymerization, but also good optical, wetting, adhesionand other physico - chemical properties without any oxygen inhibition innuence which can metthe spe-cial requirments of optical compo8ites for manufacturing of Multiplical Spherical Equation belensComplex.
