Objective： To investigate the effect of Chinese medicine （CM） and Western medicine （WM） on quality of life （QOL） after conservative surgery for endometriosis. Methods： A total of 320 patients with endometdosis...Objective： To investigate the effect of Chinese medicine （CM） and Western medicine （WM） on quality of life （QOL） after conservative surgery for endometriosis. Methods： A total of 320 patients with endometdosis were randomized into two groups by using random block design, CM group （160 cases, activating blood circulation and removing blood stasis treatment based on syndrome differentiation） and WM group （160 cases, gonadotropin-releasing hormone agonist or gestrinone treatment） after conservative surgery. Treatment was given for 3-6 months （according to the revised American Fertility Society scoring system stage）, and the Wodd Health Organization QOL-BREF （WHOQOL-BREF） was applied to patients before and after treatment to assess QOL. Results： There were 136 cases in the CM group and 141 cases in the WM group completing therapy. In the CM group, the use of the WHOQOL-BREF showed that the physical, psychological and environmental scores post- treatment were significantly higher than those at pre-treatment （P〈0.05）, and for 12 items （pain and discomfort, energy and fatigue, sleep and rest, mobility, activities of daily living, work capacity, negative feelings, health and social care： accessibility and quality, participation in and opportunities for recreation/leisure activities, appetite, QOL score, overall health status and QOL）, the difference in scores was significant （P〈0.05）. In the WM group, 4 items （pain and discomfort, opportunities for acquiring new information and skills, QOI_ score, overall health status and QOL） had significantly different scores post-treatment compared with those at pre-treatment （P〈0.05）. Before treatment, the QOL in the two groups of patients showed no significant difference （P〉0.05）. After treatment, the scores for physical health in the CM group were significantly higher than those of the WM group （P〈0.05） and the scores of 4 items （mobility, activities of daily living, sexual activity, QOL score） in the CM展开更多
目的观察黄连解毒汤对急性期脑梗死大鼠胃动力的影响。方法将60只大鼠随机分为正常对照组、假手术组、脑梗死组、枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组,每组各10只,脑梗死组、枸橼酸莫沙必利组、黄连解毒汤常规...目的观察黄连解毒汤对急性期脑梗死大鼠胃动力的影响。方法将60只大鼠随机分为正常对照组、假手术组、脑梗死组、枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组,每组各10只,脑梗死组、枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组采用线栓法制备大脑中动脉梗死模型(MCAo),假手术组大鼠仅暴露大脑中动脉而不凝闭,正常对照组不进行手术干预。造模结束后,黄连解毒汤常规剂量组和高剂量分别按生药5.39、10.78 g/kg灌胃,枸橼酸莫沙必利组按0.05 mg/kg予枸橼酸莫沙必利片灌胃,假手术组及脑梗死组予0.9%氯化钠注射液2 mL灌胃,正常对照组不做任何处理。共灌胃7 d,比较各组大鼠灌胃第4、7 d胃动素(MTL)水平情况,比较各组大鼠灌胃第1、4、7 d胃电图慢波振幅与频率情况,并分析脑梗死组大鼠胃动力障碍变化趋势。结果与正常对照组和假手术组同期比较,脑梗死组第4、7 d MTL水平均升高(P<0.05);与脑梗死组同期比较,枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组第4、7 d MTL水平均降低(P<0.05);与枸橼酸莫沙必利组同期比较,仅黄连解毒汤高剂量组第4 d MTL水平降低(P<0.05);与黄连解毒汤常规剂量组同期比较,黄连解毒汤高剂量组第4 d MTL水平降低(P<0.05)。与正常对照组和假手术组同期比较,脑梗死组大鼠第1、4、7 d胃电图慢波振幅均降低(P<0.05),其中脑梗死组第4 d胃电图慢波振幅最低(P<0.05);与脑梗死组同期比较,枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组第1、4、7 d胃电图慢波振幅均升高(P<0.05);与枸橼酸莫沙必利组同期比较,仅黄连解毒汤高剂量组第1、4、7 d胃电图慢波振幅均升高(P<0.05);与黄连解毒汤常规剂量组同期比较,黄连解毒汤高剂量组第1、4、7 d胃电图慢波振幅均升高(P<0.05)。与正�展开更多
基金Supported by the "Eleventh-Five" National Technology Support Program Project(No.2006BAI04A17)
文摘Objective： To investigate the effect of Chinese medicine （CM） and Western medicine （WM） on quality of life （QOL） after conservative surgery for endometriosis. Methods： A total of 320 patients with endometdosis were randomized into two groups by using random block design, CM group （160 cases, activating blood circulation and removing blood stasis treatment based on syndrome differentiation） and WM group （160 cases, gonadotropin-releasing hormone agonist or gestrinone treatment） after conservative surgery. Treatment was given for 3-6 months （according to the revised American Fertility Society scoring system stage）, and the Wodd Health Organization QOL-BREF （WHOQOL-BREF） was applied to patients before and after treatment to assess QOL. Results： There were 136 cases in the CM group and 141 cases in the WM group completing therapy. In the CM group, the use of the WHOQOL-BREF showed that the physical, psychological and environmental scores post- treatment were significantly higher than those at pre-treatment （P〈0.05）, and for 12 items （pain and discomfort, energy and fatigue, sleep and rest, mobility, activities of daily living, work capacity, negative feelings, health and social care： accessibility and quality, participation in and opportunities for recreation/leisure activities, appetite, QOL score, overall health status and QOL）, the difference in scores was significant （P〈0.05）. In the WM group, 4 items （pain and discomfort, opportunities for acquiring new information and skills, QOI_ score, overall health status and QOL） had significantly different scores post-treatment compared with those at pre-treatment （P〈0.05）. Before treatment, the QOL in the two groups of patients showed no significant difference （P〉0.05）. After treatment, the scores for physical health in the CM group were significantly higher than those of the WM group （P〈0.05） and the scores of 4 items （mobility, activities of daily living, sexual activity, QOL score） in the CM
文摘目的观察黄连解毒汤对急性期脑梗死大鼠胃动力的影响。方法将60只大鼠随机分为正常对照组、假手术组、脑梗死组、枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组,每组各10只,脑梗死组、枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组采用线栓法制备大脑中动脉梗死模型(MCAo),假手术组大鼠仅暴露大脑中动脉而不凝闭,正常对照组不进行手术干预。造模结束后,黄连解毒汤常规剂量组和高剂量分别按生药5.39、10.78 g/kg灌胃,枸橼酸莫沙必利组按0.05 mg/kg予枸橼酸莫沙必利片灌胃,假手术组及脑梗死组予0.9%氯化钠注射液2 mL灌胃,正常对照组不做任何处理。共灌胃7 d,比较各组大鼠灌胃第4、7 d胃动素(MTL)水平情况,比较各组大鼠灌胃第1、4、7 d胃电图慢波振幅与频率情况,并分析脑梗死组大鼠胃动力障碍变化趋势。结果与正常对照组和假手术组同期比较,脑梗死组第4、7 d MTL水平均升高(P<0.05);与脑梗死组同期比较,枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组第4、7 d MTL水平均降低(P<0.05);与枸橼酸莫沙必利组同期比较,仅黄连解毒汤高剂量组第4 d MTL水平降低(P<0.05);与黄连解毒汤常规剂量组同期比较,黄连解毒汤高剂量组第4 d MTL水平降低(P<0.05)。与正常对照组和假手术组同期比较,脑梗死组大鼠第1、4、7 d胃电图慢波振幅均降低(P<0.05),其中脑梗死组第4 d胃电图慢波振幅最低(P<0.05);与脑梗死组同期比较,枸橼酸莫沙必利组、黄连解毒汤常规剂量组及黄连解毒汤高剂量组第1、4、7 d胃电图慢波振幅均升高(P<0.05);与枸橼酸莫沙必利组同期比较,仅黄连解毒汤高剂量组第1、4、7 d胃电图慢波振幅均升高(P<0.05);与黄连解毒汤常规剂量组同期比较,黄连解毒汤高剂量组第1、4、7 d胃电图慢波振幅均升高(P<0.05)。与正�
