摘要
目的 探讨C反应蛋白(CRP)与非酒精性脂肪性肝病(NAFLD)的关系.方法 选择2012年7月至2013年10月健康体检的开滦集团公司职工为研究对象,排除饮酒者、既往心肌梗死、脑卒中、恶性肿瘤以及资料不全者,最终63 486例纳入本研究,将研究对象按血清CRP浓度分为3组,即CRP＜1 mg/L组、CRP 1～3 mg/L组和CRP＞3 mg/L组,比较各组NAFLD患者的检出率并采用多因素Logistic回归模型分析CRP与NAFLD的关系.结果 CRP＜1 mg/L组、CRP 1～3 mg/L组和CRP＞3 mg/L组NAFLD检出率分别为26.9％、42.1％和49.3％,3组比较差异有统计学意义(x2=2 192.31,P＜0.01).校正年龄、性别、腰围等混杂因素后,CRP仍与NAFLD有关联,且随着CRP浓度的增加,OR(95％ CI)值逐渐增高,分别为1.00、1.49(1.42～1.56)和1.54(1.45～1.64).结论 CRP与NAFLD发生有关联.
Objective To investigate the relationship between the C-reactive protein (CRP) and nonalcoholic fatty liver disease (NAFLD) prevalence.Methods In this study,63,486 workers who had participated in the Kailuan health examination from July 2012 to October 2013 and without history of drinking,myocardial infarction,stroke and cancer and without data incomplete were recruited.The observation population was divided into three groups according to the levels of CRP at baseline:group 1 (＜ 1 mg/L),group 2 (1-3 mg/ L) and group 3 (＞3 mg/L).The prevalence of NAFLD among three groups was observed.Multiple logistic regression was used to calculated relationship between the CRP and NAFLD prevalence.Results The prevalence of NAFLD in group 1,group 2 and group 3 were 26.9％,42.1％ and 49.3％,respectively,and the differences were significant (x2=2 192.31,P ＜ 0.01).Logistic model showed that after adjustment for age,gender,waist circumference and other confounders,the association between CRP and NAFLD was strong and the OR value (95％ CI) among the group 1,group 2 and group 3 were 1.00,1.49 (1.42-1.56),1.54 (1.45 -1.64),respectively.Conclusion CRP is independently associated with the nonalcoholic fatty liver disease.
出处
《中国综合临床》
2015年第9期-,共5页
Clinical Medicine of China
