摘要
长春西汀作为一种有效的脑血管扩张剂,在脑梗死临床治疗方面得到广泛地运用。其传统制剂存在着体内代谢迅速、消除半衰期短、生物利用度低等缺点。研究显示,将该类药物制备成自乳化控释制剂,注射用脂肪乳剂、纳米粒、微胶囊、壳聚糖微球、醇质体、栓剂等可以提高生物利用度、减慢体内消除速度、增强缓释和靶向作用。因此研制长春西汀新剂型对提高其临床疗效和新适应证的开发具有重要意义。本文通过对国内外文献的检索、整理,对国内外有关长春西汀新剂型的研究进展进行了综述。
As an effective cerebral vasodilator,vinpocetine has been widely used in the clinical treatment of cerebral infarction.Its traditional preparations have the disadvantages of rapid metabolism,short elimination half-life,and low bioavailability.Studies have shown that preparing such drugs into self-emulsification controlled release preparations,fat emulsions for injection,nanoparticles,microcapsules,chitosan microspheres,alcohol bodies,suppositories,etc.,can improve bioavailability,slow the elimination rate in vivo,and enhance sustained release and targeting effect.Therefore,the development of new vinpocetine dosage forms is of great significance to improve the clinical efficacy and development of its new indications.Through the retrieval and collation of domestic and foreign literatures,this paper summarizes the research progress of new formulations of vinpocetine at home and abroad.
作者
陆靖鹏
郑玉林
孟艳秋
LU Jing-peng;ZHENG Yu-lin;MENG Yan-qiu(Department of Pharmaceutical Engineering,Shenyang University of Chemical Technology,Shenyang 110142,China;Shanghai Maple Biological Technology Co.,Ltd.,Shanghai 201203,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2019年第12期1472-1476,共5页
Chinese Journal of New Drugs
关键词
长春西汀
给药途径
制剂
脑血管病
vinpocetine
route of administration
preparation
cerebrovascular disease
