摘要
比较了 6种国产和进口微晶纤维素 PH10 1的粒径、流动性和溶胀性等 ,采用直接压片法 ,考察了两种不同模型药物压成片剂的崩解度和溶出度。结果表明 ,部分国产微晶纤维素的质量已达到或优于进口产品。
The properties such as granularity, fluidity and swelling capacity of domestic and imported microcrystalline cellulose (MCC) PH101 were investigated and compared. The disintegration and dissolution of metoprolol tartrate tablets and atenolol tablets prepared with six brands of MCC respectively and by direct powder compression method were determined. The results indicated that the profiles of some domestic MCC were comparable to the imported ones.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第11期561-563,共3页
Chinese Journal of Pharmaceuticals
关键词
微晶纤维素
崩解度
溶出度
直接压片法
microcrystalline cellulose
disintegration
dissolution
powder compression method
