摘要
背景:目前现代医疗手段治疗膝骨关节炎仍具有一定局限性,中药生物碱类成分可通过多种作用机制有效防治膝骨关节炎。目的:对中药生物碱类成分防治膝骨关节炎的作用机制进行综述,为临床开发治疗膝骨关节炎的药物提供科学依据。方法:查阅中国知网、万方、Pub Med、Web of Science和Google Scholar数据库从建库至2024年5月发表的相关文献,中文检索词为“膝骨关节炎,骨关节炎,破骨细胞,软骨细胞,生物碱”,英文检索词为“knee osteoarthritis,osteoarthritis,osteoclast,chondrocyte,alkaloids”,排除陈旧及无参考意义的文献,最终纳入68篇文献进行综述。结果与结论:虽然中药治疗膝骨关节炎的历史悠久,但仅有少量的天然化合物处于抗膝骨关节炎的临床前研究阶段,生物碱类成分对于防治膝骨关节炎具有较大潜能,其中苦参碱、氧化苦参碱、青藤碱、甜菜碱等已被证实可通过调控多条信号通路抑制炎症反应、抗氧化反应、抑制软骨细胞凋亡、促进软骨细胞增殖、抑制破骨细胞形成与分化等延缓膝骨关节炎的进展。
BACKGROUND:At present,modern medical treatment has certain limitations on the treatment of knee osteoarthritis.Traditional Chinese medicine alkaloids can effectively prevent and treat knee osteoarthritis through various mechanisms.OBJECTIVE:To review the mechanism of alkaloids in traditional Chinese medicine in the prevention and treatment of knee osteoarthritis,providing a scientific basis for the clinical development of drugs for the treatment of knee osteoarthritis.METHODS:CNKI,WanFang,PubMed,Web of Science and Google Scholar were retrieved for relevant literature published from database inception to May 2024.The key words were“knee osteoarthritis”“osteoarthritis”“osteoclast”“chondrocyte”“alkaloids”in Chinese and English.Duplicates and obsolete non-referenced literature were excluded,and a total of 68 eligible papers were included for further review.RESULTS AND CONCLUSION:Although traditional Chinese medicine has a long history of treating knee osteoarthritis,only a small number of natural compounds are in the preclinical stage of research against knee osteoarthritis.Alkaloids have a greater potential for the prevention and treatment of knee osteoarthritis,among which,sophocarpidine,oxymatrine,sinomenine,and betaine have been shown to be effective in the prevention and treatment of knee osteoarthritis by modulating multiple signaling pathways.Alkaloids can delay the progression of knee osteoarthritis by inhibiting inflammatory response,exerting antioxidant response,inhibiting chondrocyte apoptosis,promoting chondrocyte proliferation,and inhibiting osteoclast formation and differentiation.
作者
沈栩钰
罗承诺
章晓云
江周影
柴源
Shen Xuyu;Luo Chengnuo;Zhang Xiaoyun;Jiang Zhouying;Chai Yuan(Guangxi University of Chinese Medicine,Nanning 530011,Guangxi Zhuang Autonomous Region,China;Ruikang Hospital,Guangxi University of Chinese Medicine,Nanning 530011,Guangxi Zhuang Autonomous Region,China)
出处
《中国组织工程研究》
CAS
北大核心
2025年第11期2368-2376,共9页
Chinese Journal of Tissue Engineering Research
基金
广西高校中青年教师科研基础能力提升项目(2024KY0300),项目负责人:柴源
广西中医药大学青年科学基金项目(2023QN010),项目负责人:柴源。
关键词
膝骨关节炎
中药
生物碱类
信号通路
破骨细胞
软骨细胞
细胞自噬
knee osteoarthritis
traditional Chinese medicine
alkaloids
signaling pathway
osteoclast
chondrocyte
autophagy
