摘要
目的了解肿瘤微环境(tumor microenvironment,TME)中免疫细胞的调节机制、免疫治疗的新靶点以及中药成分对免疫细胞的调节作用。方法查阅相关文献,总结TME中免疫细胞调控机制和发挥抗肿瘤免疫治疗的新靶点以及中药成分对免疫细胞的调节作用。结果总结了肿瘤微环境中T细胞、巨噬细胞、树突状细胞在分化、发育、功能上的调控机制,归纳了抗肿瘤免疫治疗的新靶点,基于这些调控机制分析不同种类的中药成分对免疫细胞的调控作用。结论梳理总结TME中免疫细胞的自身调控机制和中药成分对免疫细胞的调节作用,为中药抗肿瘤免疫机制的深入探索奠定基础。
Objective To study the regulatory mechanisms of immune cells in tumor microenvironment(TME)and new targets for immunotherapy,as well as the effects of Chinese herbal ingredients on immune cells.Methods The regulatory effects of immune cell in TME,the new targets for anti-tumor immunotherapy and the effects of Chinese herbal ingredients on immune cells were summarized by referring to relative literatures.Results The regulatory mechanisms of T cells,macrophages and dendritic cells in TME were reviewed in terms of differentiation,development and function.Several new targets for anti-tumor immunotherapy and regulatory effects of different kinds of Chinese herbal medicine components on immune cells were summarized and analyzed.Conclusion Reviewing the self-regulatory mechanisms of immune cells in TME and the effects of Chinese herbal ingredients on immune cells could lay a foundation for the exploration of anti-tumor immune mechanism of traditional Chinese medicine.
作者
呼宇
曹寒冰
龚政艳
朱曼
代秉玲
张彦民
HU Yu;CAO Hanbing;GONG Zhengyan;ZHU Man;DAI Bingling;ZHANG Yanmin(School of Pharmacy,Health Science Center,Xi’an Jiaotong University,Xi’an 710061,China)
出处
《西北药学杂志》
2024年第1期211-220,共10页
Northwest Pharmaceutical Journal
基金
国家自然科学基金青年基金项目(编号:82104213)
陕西省重点产业创新链(群)项目(编号:2022ZDLSF05-05)
陕西省中医药管理局秦药重点专项(编号:2021-03-ZZ-002)
陕西省杰出青年科学基金项目(编号:2023-JC-JQ-59)。
关键词
肿瘤微环境
抗肿瘤免疫
免疫细胞
中药免疫调控
tumor microenvironment
anti-tumor immunity
immune cells
immunomodulation by traditional Chinese medicine
