摘要
目的:探讨序贯移植方案在高龄不孕症患者冷冻胚胎解冻移植中的应用,比较序贯移植、移植2枚卵裂胚、移植2枚囊胚3种方案的临床妊娠结局,为高龄不孕患者在行冷冻胚胎解冻移植周期中的胚胎选择方案提供新的思路。方法:选取2017年7月—2021年5月厦门大学附属第一医院生殖医学中心行冷冻胚胎解冻移植的150例高龄不孕患者(年龄≥35岁)作为研究对象,按移植胚胎种类分为A组(序贯移植n=30)、B组(移植2枚卵裂胚n=60)和C组(移植2枚囊胚n=60)。回顾性分析比较三组患者年龄、抗缪勒管激素(AMH)、基础性激素、转化日内膜厚度、优质胚胎移植比率、临床妊娠率、多胎妊娠率和流产率。结果:三组患者的年龄、AMH、优质胚胎移植比率、多胎妊娠率、流产率比较,差异无统计学意义(F=0.735、1.581、0.589、2.987、0.456,P>0.05)。A组患者的临床妊娠率及胚胎种植率均明显高于B组及C组,差异有统计学意义(χ^(2)=0.042、6.569,P<0.05)。结论:序贯周期在高龄不孕患者的冷冻胚胎移植中能得到更好的临床结局,可成为高龄不孕患者解冻移植的一种有效选择胚胎方案。
Objective:To investigate the application of sequential transfer protocols in the thawing transfer of frozen embryos in patients with advanced infertility.To compare the clinical pregnancy outcomes of three protocols:sequential transfer,transfer of two oocytes,and transfer of two blastocysts,and to provide new ideas for embryo selection in thawing transfer cycles of frozen embryos in advanced infertility patients.Methods:A total of 150 cases of advanced infertility patients(age≥35 years)who underwent fro⁃zen embryo thawing transfer in the hospital from July 2017 to May 2021 were selected and divided into group A(sequential trans⁃fer,n=30),group B(transfer of 2 oocytes,n=60)and group C(transfer of 2 blastocysts,n=60)according to the type of embryos transferred.Age,AMH,basal sex hormones,endometrial thickness at the day of conversion,quality embryo transfer rate,clinical pregnancy rate,multiple pregnancy rate and miscarriage rate were retrospectively analyzed and compared in both groups.Results:There was no statistically significant difference in age,AMH,high-quality embryo transfer rate,multiple pregnancy rate,and mis⁃carriage rate among the three groups(F=0.735,1.581,0.589,2.987,0.456,P>0.05).The clinical pregnancy rate and embryo im⁃plantation rate of patients in group A were significantly higher than those in group B and group C,with statistically significant dif⁃ferences(χ^(2)=0.042,6.569,P<0.05).Conclusion:Sequential cycles can yield better clinical outcomes in frozen-thawed embryo transfer in patients with advanced infertility and can be an effective option for thawing embryos for transfer in patients with ad⁃vanced infertility.
作者
王蕾
许淑芬
WANG Lei;XU Shu-fen(Center for Reproductive Medicine,The First Hospital of Xiamen University,Xiamen,Fujian,361003,China)
出处
《黑龙江医学》
2023年第8期905-907,911,共4页
Heilongjiang Medical Journal
基金
厦门大学附属第一医院院内科研资助课题(XYY2017015)。
关键词
高龄
不孕
序贯移植
冷冻胚胎移植
妊娠率
Advanced age
Infertility Sequential embryo transfer
Frozen-thawed embryo transfer
Pregnancy rate
