摘要
目的探究健脾化痰方对脾虚痰湿证多囊卵巢综合征胰岛素抵抗(PCOS-IR)患者子宫内膜容受性、抗苗勒管激素(AMH)的影响。方法选取2019年3月至2021年5月就诊于湖南中医药大学第二附属医院的120例脾虚痰湿证PCOS-IR患者作为研究对象,以随机数字表法分为观察组和对照组,各60例。对照组给予常规治疗,观察组在对照组基础上联合健脾化痰方治疗。于治疗3个月后,比较两组临床疗效及子宫内膜容受性、性激素水平、糖脂代谢指标。结果观察组治疗总有效率高于对照组,治疗后子宫内膜厚度大于对照组,搏动指数(PI)、阻力指数(RI)小于对照组(P<0.05);观察组A型子宫内膜检出率高于对照组(P<0.05);观察组治疗后AMH、睾酮(T)水平低于对照组,空腹血糖(FBG)水平低于对照组,胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)小于对照组(P<0.05);观察组治疗后三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平低于对照组,高密度脂蛋白胆固醇(HDL-C)水平高于对照组,临床妊娠率高于对照组(P<0.05)。结论健脾化痰方治疗脾虚痰湿证PCOS-IR,可增加患者子宫内膜容受性,改善机体糖脂代谢及性激素水平,提高临床妊娠率。
Objective To explore the effects of Jianpi Huatan Decoction on endometrial receptivity and anti-Müllerian hormone(AMH)in patients with polycystic ovary syndrome and insulin resistance(PCOS-IR)of spleen deficiency and phlegm-dampness syndrome.Methods 120 patients with PCOS-IR of spleen deficiency and phlegm-dampness syndrome admitted to the Second Affiliated Hospital of Hunan University of Chinese Medicine from March 2019 to May 2021 were selected as the study subjects and were divided into observation group and control group by the random number table method,with 60 cases in each group.The control group was given routine treatment,and the observation group was treated with Jianpi Huatan Decoction on the basis of the control group.After 3 months of treatment,the clinical efficacy,endometrial receptivity,sex hormones levels and glucolipid metabolism indicators were compared between the two groups.Results The total effective rate of treatment in observation group was higher than that in control group,and the endometrial thickness after treatment was thicker than that in control group,and the pulsatility index(PI)and resistance index(RI)were lower than those in control group(P<0.05).The detection rate of type A endometrium in observation group was higher than in control group(P<0.05).The levels of AMH and testosterone(T)in observation group after treatment were lower than those in control group,and the fasting blood glucose(FBG)level was lower than that in control group,and the fasting insulin(FINS)and homeostasis model assessment of insulin resistance(HOMA-IR)were lower than those in control group(P<0.05).After treatment,the levels of triglyceride(TG),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)in observation group were lower than those in control group while the level of high-density lipoprotein cholesterol(HDL-C)was higher than that in control group,and the clinical pregnancy rate was higher in observation group than that in control group(P<0.05).Conclusions Jianpi Huatan Decoction in the t
作者
李岚
杨正望
余曦明
LI Lan;YANG Zhengwang;YU Ximing(Department of Gynecology,the Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005,Hunan,China;Department of Gynecology,the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410021,Hunan,China;Hunan University of Chinese Medicine,Changsha 410017,Hunan,China)
出处
《中国性科学》
2023年第4期103-107,共5页
Chinese Journal of Human Sexuality
基金
湖南省自然科学基金(2019JJ50459)。
关键词
健脾化痰方
脾虚痰湿证
多囊卵巢综合征胰岛素抵抗
子宫内膜容受性
抗苗勒氏管激素
Jianpi Huatan Decoction
Spleen deficiency and phlegm-dampness syndrome
Polycystic ovary syndrome and insulin resistance
Endometrial receptivity
Anti-Müllerian hormone
