摘要
目的分析12274例有上呼吸道感染症状的老年(年龄≥60岁)患者常见呼吸道病毒感染情况。方法2017年1月1日—2021年12月31日间中国医科大学附属第四医院收治的12274例有上呼吸道感染的老年患者,采集外周血3 mL,采用ELISA法检测血清A型流感病毒(AIV)、B型流感病毒(BIV)、副型流感病毒(PIV)、呼吸道合胞病毒(RSV)、人类巨细胞病毒(HCMV)、腺病毒(ADV)和柯萨奇病毒(COX)及EB病毒,分析呼吸道病毒的流行病学特征。结果12274例样本的呼吸道病毒IgM抗体阳性率27.24%,其中PIV、BIV、VCA、ADV、COX、HCMV、RSV、AIV IgM抗体阳性率分别为5.05%、1.11%、3.32%、3.86%、1.18%、4.81%、0.13%。与男性比较,女性老年患者血清HCMV IgM抗体阳性率高(χ^(2)为5.51,P<0.05)。与其余各年比较,2021年老年患者血清BIV IgM抗体阳性率低(P均<0.05)。与其他季节比较,老年患者春季PIV IgM抗体阳性率高,夏季RSVIgM抗体阳性率高(χ^(2)分别为7.92、126.7,P均<0.05)。结论有上呼吸道感染症状的老年患者呼吸道病毒感染以PIV、BIV、ADV、COX、RSV感染为主。老年患者呼吸道病毒感染与性别、年龄、季节及年份密切相关,随年龄增长,老年患者呼吸道PIV、RSV感染比例升高,女性老年患者更易感染呼吸道病毒,老年患者呼吸道病毒感染集中在春季和夏季,2021年老年患者呼吸道病毒感染主要为BIV感染。
Objective To analyze the common respiratory virus infections of 12274 elderly patients(aged≥60 years)with upper respiratory tract infection symptoms.Methods From January 1,2017 to December 31,2021,12274 elderly patients with upper respiratory tract infection were admitted to the Fourth Affiliated Hospital of China Medical University.The peripheral blood of 3 mL was collected from each patient.Respiratory viruses,including serum influenza A virus(AIV),influenza B virus(BIV),parainfluenza virus(PIV),respiratory syncytial virus(RSV),human cytomegalovirus(HCMV),adenovirus(ADV),Coxsackie virus(COX),and EB virus,were detected by ELISA.The epidemiological characteristics of respiratory viruses were analyzed.Results The positive rate of IgM antibody in 12274 samples was 27.24%,and the positive rates of PIV,BIV,VCA,ADV,COX,HCMV,RSV and AIV IgM antibody were 5.05%,1.11%,3.32%,3.86%,1.18%,4.81%and 0.13%,respectively.The positive rate of serum HCMV IgM antibody in elderly female patients was higher than that in male patients(χ^(2)was 5.51,P<0.05).Compared with other years,the positive rate of serum BIV IgM in the elderly patients in 2021 was lower(all P<0.05).Compared with other seasons,the positive rate of PIV IgM antibody was higher in spring and RSV IgM antibody was higher in summer(χ^(2)were 7.92 and 126.7,all P<0.05).Conclusions PIV,BIV,ADV,COX,RSV are the main respiratory virus infections in elderly patients with upper respiratory tract infection symptoms.Respiratory virus infection in elderly patients is closely related to gender,age,season and year.With the increase of age,the proportion of PIV and RSV infection in elderly patients increases.Elderly female patients are more susceptible to respiratory virus infection.Respiratory virus infection in elderly patients is concentrated in spring and summer.The main respiratory virus infection in elderly patients was BIV in 2021.
作者
尚丹
张浩
何丽
周霞
SHANG Dan;ZHANG Hao;HE Li;ZHOU Xia(Clinical Laboratory,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China)
出处
《山东医药》
CAS
2022年第30期34-37,共4页
Shandong Medical Journal
