摘要
目的分析炎症标志物IL-6、IL-8和IL-10作为胸腔镜肺癌根治术后患者肺部感染早期预测指标的准确性。方法选取行胸腔镜肺癌根治术患者136例,将术后7天内继发肺部感染者作为感染组(n=23),未继发肺部感染者作为对照组(n=113)。回顾患者术后6 h内的血清IL-6、IL-8和IL-10水平;使用Logistic回归分析各炎症指标与术后继发肺部感染的相关性;绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析血清炎症指标与术后继发肺部感染预后价值。结果感染组的血清IL-6、IL-8水平均高于对照组(P<0.05);IL-10水平高于对照组,但无统计学差异,Logistic分析说明IL-6、IL-8和IL-10水平增高均是肺癌术后肺部感染的独立影响因素。IL-6、IL-8和IL-10联合预测肺癌术后肺部感染的曲线下面积为0.793(95%CI:1.215~1.761,P=0.006),高于单一指标预测的曲线下面积。结论胸腔镜肺癌根治术后血清IL-6、IL8和IL-10水平增高是术后继发肺部感染的独立影响因素;对IL-6、IL-8、IL-10联合检测具有对胸腔镜肺癌根治术后继发肺部感染具有更高的预测价值。
Objective To analyze the accuracy of inflammatory markers IL-6,IL-8 and IL-10 as early predictors of pulmonary infection after thoracoscopic radical resection of lung cancer.Methods 136 patients who underwent thoracoscopic radical resection of lung cancer were selected.Secondary lung infection within 7 days after surgery was selected as the infection group(n=23),and no secondary lung infection was selected as the control group(n=113).Serum IL-6,IL-8 and IL-10 levels within 6 h after surgery were reviewed.Logistic regression was used to analyze the correlation between inflammatory indexes and postoperative pulmonary infection.The receiver operating characteristic(ROC)curve was drawn to analyze the prognostic value of serum inflammatory indexes and secondary pulmonary infection after surgery.Results The levels of serum IL-6 and IL-8 in infection group were higher than those in control group(P<0.05).The level of IL-10 was higher than that of the control group,but there was no statistical difference.Logistic analysis showed that increased LEVELS of IL-6,IL-8 and IL-10 were independent influencing factors of lung infection after lung cancer surgery.Il-6,IL-8 and IL-10 combined predicted the area under the curve of postoperative lung cancer infection was 0.793(95%CI:1.215~1.761,P=0.006),which was higher than that predicted by single indicator.Conclusion Increased serum IL-6,IL-8 and IL-10 levels after thoracoscopic radical resection of lung cancer are independent influencing factors of postoperative pulmonary infection.The combined detection of IL-6,IL-8 and IL-10 has higher predictive value for secondary pulmonary infection after thoracoscopic radical resection of lung cancer.
作者
何锋
陈新富
王小英
刘宁
陈树兴
林铿强
HE Feng;CHEN Xinfu;WANG Xiaoying(Fuzhou Pulmonary Hospital,Teaching Hospital of Fujian Medical University,Fuzhou,350007)
出处
《实用癌症杂志》
2022年第7期1174-1177,共4页
The Practical Journal of Cancer
基金
福州市级科技计划项目(编号:2020-WS-117)
福州市2019年临床重点专科建设项目(编号:201912003)。
