摘要
目的分析不同剂量孕激素治疗无排卵型月经失调的疗效。方法400例无排卵型月经失调患者,随机分为低剂量组、中等剂量组、较高剂量组、高剂量组,每组100例,分别给予100、200、300、400 mg/d的黄体酮治疗。比较四组临床治疗效果、不良反应发生率。结果四组治疗总有效率比较差异无统计学意义(P>0.05)。低剂量组不良反应发生率2.00%低于中等剂量组的15.00%、较高剂量组的16.00%、高剂量组的17.00%,差异有统计学意义(P<0.05)。结论不同剂量孕激素治疗无排卵型月经失调均有效,但低剂量孕激素不良反应相对较小,安全可靠。在临床使用当中,不同剂量100、200、300、400 mg/d的孕激素治疗无排卵型月经失调的疗效相似,而选择100 mg/d剂量的孕激素,对患者的损害最轻,也可一定程度减轻患者用药经济负担。
Objective To analyze the efficacy of different doses of progesterone on anovulatory menstrual disorder.Methods A total of 400 patients with anovulatory menstrual disorders were randomly divided into low-dose group,medium-dose group,higher-dose group,and high-dose group,with 100 cases in each group.They received 100,200,300 and 400 mg/d of progesterone treatment respectively.The clinical effect and incidence of adverse reactions in the four groups were compared.Results There was no statistically significant difference in the total treatment efficiency between the four groups(P>0.05).The incidence of adverse reactions in the low-dose group was 2.00%,which was lower than 15.00%in the medium-dose group,16.00%in the higher-dose group,and 17.00%in the high-dose group,and the difference was statistically significant(P<0.05).Conclusion Different doses of progesterone are effective in treating anovulatory menstrual disorders,but low doses of progesterone have relatively fewer adverse reaction of progesterone and are safe and reliable.In clinical use,different doses(100,200,300 and 400 mg/d)of progestogen have similar efficacy on menstrual disorders,while 100 mg/d of progestogen has the least damage to patients and can also reduce the economic burden of medication to a certain extent.
作者
刘宇
LIU Yu(Dalian Liaoyu Hospital,Dalian 116113,China)
出处
《中国现代药物应用》
2022年第7期102-104,共3页
Chinese Journal of Modern Drug Application
关键词
无排卵型
月经失调
孕激素
不同剂量
疗效
Anovulatory
Menstrual disorders
Progesterone
Different doses
Efficacy
