摘要
复发性流产(recurrent spontaneous abortion,RSA)是生殖育龄期女性的常见疾病,其发病机制尚不完全清楚。近年来,随着表观遗传学领域的深入研究,DNA甲基化逐渐成为RSA病理生理机制的新视角。研究表明,DNA甲基化修饰调控与RSA密切相关,DNA甲基化异常及其引起的印迹障碍、蜕膜相关基因表达失调、精子缺陷以及免疫系统异常都直接或间接地影响胚胎的着床、生长及发育过程,最终导致RSA的发生。现阐述DNA甲基化在RSA发病中的作用及其调控途径的研究进展。
Recurrent spontaneous abortion(RSA)is a common disease in women of reproductive age,and the pathogenesis is not fully understood.In recent years,with in-depth research in the field of epigenetics,DNA methylation has gradually become a new perspective on the pathophysiology of RSA.Studies have shown that the regulation of DNA methylation modification is closely related to RSA.Abnormal DNA methylation and its imprinting disorders,dysregulated gene expression disorders,sperm defects and immune system abnormalities directly or indirectly affect embryo implantation.The growth and development process eventually lead to the occurrence of RSA.The role of DNA methylation in the pathogenesis of RSA and its regulatory pathways are reviewed.
作者
平昀鹭
蒋莎
赵小萱
冯晓玲
Ping Yunlu;Jiang Sha;Zhao Xiaoxuan;Feng Xiaoling(Heilongjiang University of Chinese Medicine,Harbin 150040,China;the First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中华生殖与避孕杂志》
CSCD
北大核心
2021年第4期372-376,共5页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金面上项目(81973894)
黑龙江中医药大学“优秀创新人才支持计划”项目(2018RCL12)
黑龙江中医药大学校基金(2019MS34)。
关键词
表观遗传
DNA甲基化
复发性流产
胚胎发育
Epigenetics
DNA methylation
Recurrent spontaneous abortion
Embryonic development
