摘要
脊髓损伤(spinal cord injury,SCI)是一种高致残性疾病,会严重降低患者的运动能力和健康期望寿命,给患者的家庭和社会带来巨大的损失。从前人研究的结果来看,胶质瘢痕对SCI的影响很大,关于其发挥的是正面作用还是负面作用的讨论从未停止。无论如何,掌握减少SCI后胶质瘢痕形成的方法可为进一步地治疗SCI、帮助神经元再生和恢复运动与感觉提供一种选择。故本文将近三年对减少SCI后胶质瘢痕形成的方法进行综述。在今后的研究中研究者们可在现有研究的基础上努力实现更精准有效、可及性更高和更安全的应用,且可进行联合治疗以更好地减少刺激性和危险性,努力推进更多安全有效的方法进入临床,解除SCI患者的病痛。
Spinal cord injury(SCI)is a highly disabling disease,which will seriously reduce the patients′mobility,disability adjusted life expectancy,cause huge losses to patients′families and society.Even the discussion about whether glial scarsexerteda positive or negative effect not stopped,previous studies showed that glial scars had a great impact on SCI.In any case,mastering the method of reducing glial scar formation after SCI would provide a choice for further treatment of SCI,helping neuron regeneration and restoring movement and sensation.There fore,we reviewed the methods of reducing glial scar formation after SCI in the past three years.In future research,researchers could work harder to achieve more precise,effective,accessible,and safe applications based on exist⁃ing research.Carrying out combination therapy would reduce irritation and risk.It would also promote more safe and effective methods into the clinic and thus relieve the pain of patients with SCI.
作者
韦入菲
曾高峰
WEI Rufei;ZENG Gaofeng(School of Public Health,Guangxi Medical University,Nanning 530021,China)
出处
《实用医学杂志》
CAS
北大核心
2020年第20期2876-2880,共5页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:81860391)。
关键词
胶质瘢痕
脊髓损伤
方法
glial scar
spinal cord injury
method
