摘要
目的系统评价胃癌组织中人乳头瘤病毒16型(human papillomavirus 16,HPV16)的感染情况及其与临床病理特征的关系。方法计算机检索Pubmed、EMbase、MEDLINE、Web of Secience、Cochrane Library、万方、维普、中国知网和中国生物医学文献数据库(CBM),收集有关HPV16和胃癌关系的文献,检索时限为自建库日期至2019年1月,由2位研究人员按照纳入与排除标准独立进行文献筛选、资料提取,并运用改良纽卡斯尔-渥太华量表(NOS)对文章的质量进行系统评价。应用RevMan 5.3软件进行Meta分析,并计算比值比(odds ratio,OR)及其95%可信区间(95%CI)。结果最终共纳入16篇文献,其中胃癌组1066例,对照组562例。Meta分析结果显示:HPV16感染率在胃癌组与对照组(OR=5.76,95%CI:3.08~10.78,P<0.01)、胃癌分化程度中高分化组与低未分化组(OR=0.58,95%CI:0.40~0.85,P=0.005)、胃癌发生部位贲门组与非贲门组(OR=3.52,95%CI:2.11~5.90,P<0.01)、胃癌TNM分期Ⅰ~Ⅱ期与Ⅲ~Ⅳ期(OR=2.23,95%CI:1.09~4.56,P=0.03)中的差异均有统计学意义,而与胃癌患者的年龄、性别及胃癌的浸润深度、有无淋巴结转移无统计学相关性(均P>0.05)。结论胃癌组织中HPV16的感染率高于非癌变胃黏膜组织,且与胃癌分化程度、发生部位、TNM分期相关。HPV16可能参与了胃组织细胞的恶性转化,HPV16感染是胃癌的风险因素,且与胃癌的发生发展过程相关。但由于纳入文献数量及质量限制,该研究结论尚需更多的大样本研究及相关实验证实。
Objective To investigate the prevalence of human papillomavirus 16(HPV16)infection in gastric cancer tissues and its relationship with clinicopathological features with a systematic review.Methods Reports on relationship between infection of HPV16 and the clinicopathological features of gastric cancer published before January,2019 were searched through the databases including PubMed,EMbase,MEDLINE,Web of Science,Cochrane Library,WanFang,VIP,China National Knowledge Infrastructure(CNKI)and China Biology Medicine database(CBM).Two reviewers screened the literature and extracted the data independently based on the inclusion and exclusion criterion.The improved Newcastle-Ottawa Scale(NOS)was used to systematically assess the methodological quality of included studies.And Review Manager 5.3 was adopted to calculate the odds ratio(OR)and 95% confidence interval(95%CI)for this Meta-analysis.Results A total of 16 studies involving 1066 cases in gastric cancer group and 562 cases in control group were included in this Meta-analysis.The Meta-analysis revealed there were significant differences in prevalence of HPV16 infection between gastric cancer tissues and non-cancerous gastric tissues(OR=5.76,95%CI:3.08-10.78,P<0.01),between high/moderate differentiation gastric cancer tissues and low/non-differentiation tissues(OR=0.58,95%CI:0.40-0.85,P=0.005),between cardia gastric cancer and non-cardia gastric cancer(OR=3.52,95%CI:2.11-5.90,P<0.01),and between cancer tissues with clinical TNM stages Ⅰ to Ⅱ and those with clinical TNM stages Ⅲ to Ⅳ(OR=2.23,95%CI:1.09-4.56,P=0.03).However,prevalence of HPV16 infection was not significantly associated with the age and gender of gastric cancer patients,as well as depth of invasion,and metastasis of lymph nodes of gastric cancer(P>0.05).Conclusion The prevalence of HPV16 infection in gastric cancer tissues is higher than that in non-cancerous gastric tissues,and it is related to the differentiation degree,location and TNM stages of gastric cancer.HPV16 infection may increase the
作者
邓雯之
谷永红
Deng Wenzhi;Gu Yonghong(Department of Pathology,the Third Xiangya Hospital of Central South University,Changsha 410006,China)
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2020年第1期81-88,共8页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
湖南省自然科学基金资助项目(No.2017JJ2371)。
关键词
胃癌
HPV16
临床病理
META分析
gastric cancer
human papillomavirus 16
clinicopathological feature
Meta-analysis
