摘要
目的运用扩散张量成像技术(DTI)及基于纤维束示踪空间统计分析(TBSS)方法研究酒依赖患者脑白质微结构的改变。方法对30例酒精依赖者(患者组)和30例健康志愿者(对照组)进行全脑DTI数据采集。通过TBSS方法比较两组间各向异性分数(FA)、平均扩散系数(MD)、轴向扩散系数(AD)和径向扩散系数(RD)的差异。对患者组差异区域的FA值与蒙特利尔认知评估量表(MoCA)评分及嗜酒年限进行Pearson相关性分析。结果与正常对照组比较:患者组胼胝体膝部、体部及压部、右侧钩状束、右侧上纵束、右侧下纵束、右侧下额枕束、两侧丘脑前辐射及两侧穹窿/终纹体FA值减低(P<0.05,FWE校正);胼胝体体部、右侧钩状束、右侧上纵束、两侧丘脑前辐射及两侧穹窿/终纹体束MD值增加(P<0.05,FWE校正);胼胝体膝部、体部及压部、右侧上纵束、右侧下额枕束、两侧扣带束、两侧丘脑前辐射、两侧穹窿/终纹体束及两侧钩状束RD值增加(P<0.05,FWE校正);两组AD值比较差异无统计学意义(P>0.05,FWE校正);全脑FA均值与嗜酒年限呈负相关(r=-0.464);胼胝体压部FA值与视空间和执行功能正相关(r=0.391)。结论酒依赖患者存在广泛的脑白质纤维微结构改变及认知功能障碍,白质纤维以脱髓鞘改变为主,脑白质结构损害随其酒精依赖时间而持续进展。
Objective To analyze the microstructural change of white matter (WM) in alcohol-dependent patients using diffusion tensor imaging (DTI). Methods Whole brain DTI was acquired on 30 AD patients and 30 healthy controls. Multiple parameters, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were compared between the two groups using tract-based spatial statistics (TBSS). Pearson correlation analysis was used to explore the relationship of FA value with the Montreal Cognitive Assessment (MoCA) scores and duration of alcohol dependence. Results Compared with the control, alcohol-dependent patients had significantly (P<0.05, FWE correction) decreased FA values in the genu, body and splenium of corpus callosum, right uncinate fasciculus (UNF), right superior longitudinal fasciculus (SLF), right inferior longitudinal fasciculus (ILF), right inferior frontal occipital fasciculus (IFOF), bilateral fornix/striatum and anterior thalamic radiation (ATR) whereas the RD values were significantly (P<0.05, FWE correction) decreased in the aforementioned regions as well as left UNF and bilateral cingulum. MD was significantly (P<0.05, FWE correction) increased only in the body of corpus callosum, right UNF, bilateral fornix, striatum, and ATR. The difference of AD in all areas was not significant between the two groups (P>0.05, FWE correction). Pearson correlation analysis showed that the global FA values were negatively correlated with the duration of alcohol dependence (r=-0.464), and the FA values of splenium of corpus callosum were positively correlated with the spatial, visual and executive function scores of MoCA (r=0.391). Conclusion Alcohol-dependent patients have extensive progressive WM microstructural changes and cognitive dysfunction, which may reflect the WM demyelination.
作者
张海波
余金鸣
戴西勇
张建龙
姚晓英
黄湘漪
ZHANG Hai-bo;YU Jin-ming;DAI Xi-yong;ZHANG Jian-long;YAO Xiao-ying;HUANG Xiang-yi(Department of Medical Imaging, The Third People's Hospital of Zhongshan City, Guangdong 528451, China)
出处
《影像诊断与介入放射学》
2019年第2期90-95,共6页
Diagnostic Imaging & Interventional Radiology
基金
广东省医学科研基金项目(B2015123)
中山市社会公益科技研究项目(2018B1051)
