摘要
目的探讨亚临床甲状腺功能减退症(SCH)与冠状动脉粥样硬化性心脏病(冠心病)的关系。方法选取行冠状动脉造影(CAG)患者231例为研究对象,其中冠心病162例设为冠心病组,非冠心病者69例设为对照组,同时冠心病组根据病变支数又分为单支组74例和多支组88例。检查受试者游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、超敏促甲状腺激素(s-TSH)水平,检测总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。结果 1冠心病组SCH患病率高于对照组(P<0.01),多支组SCH患病率高于单支组(P<0.01);2冠心病组s-TSH水平高于对照组(P<0.05),多支组s-TSH水平高于单支组(P<0.05);3按有无SCH分层,冠心病组中SCH患者TC、LDLC水平高于无SCH患者(P<0.01)。结论 SCH是冠心病发生危险因素,可能和SCH影响血脂代谢有关。
Objective To investigate the correlation between subclinical hypothyroidism （SCH） and coronary atherosclerosis disease （CAD）. Methods A total of 231 patients underwent coronary angiography （CAG） were assigned to CAD group （n = 162） and non-CAD group （n = 69）. In the CAD group, patients were divided into single-vessel group （ n = 74） and multi-vessel group （ n = 88） according to the number of lesion vessels. All research subjects received detection of free 3, 5, 3 triiodothyronine （FT3 ）, free thyroxine （FT4）, hypersensitive thyroid stimulating hormone （s-TSH）, total Cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C）. Result （1） The incidence rate of SCH was higher in the CAD group than that in the non - CAD group （ 6 2 / 1 6 2 vs. 1 3 / 6 9, P 〈 0.01）, and that was also higher in the multi-vessel group than the single-vessel group （43/88 vs. 19/74, P〈0.01） ; （2） The level of s-TSH was higher in the CAD group than that in the non-CAD group [ （4.65 ± 2.86） mU/L vs. （3.85± 2.04） mU/L, P 〈 0.05 ], and that was also the higher in multi-vessel group than the single-vessel group [ （5.01 ± 3.10） mU/L vs. （4.02 ±3.21） rnU/ L, P〈0.05]. （3） Levels of TC and LDL-C were higher in the CAD patients with SCH than the CAD patients without CAD （P〈0.01）. Conclusion SCH is a potential risk factor of CAD, and it may be correlated with influence of lipids metabolism by SCH.
出处
《实用临床医药杂志》
CAS
2015年第13期19-22,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11522553)
