摘要
目的研究元宝草Hypericum sampsonii地上部分的化学成分。方法采用HP-20大孔吸附树脂柱色谱、硅胶柱色谱、ODS柱色谱、RP-HPLC分离手段进行分离纯化,利用波谱学的方法鉴定化合物结构。结果从元宝草地上部分60%乙醇提取物中分离得到4个化合物,分别鉴定为2,4,6-三甲氧基-3′,5′-二羟基二苯甲酮(1)、2,4,6-三甲氧基-3′-羟基二苯甲酮-5′-O-α-L-吡喃鼠李糖苷(2)、2-羟基-4,6-二甲氧基二苯甲酮(3)、2,4,6,3′,5′-五甲氧基二苯甲酮(4)。结论化合物1和2为2个新的二苯甲酮类化合物,分别命名为元宝草素A和元宝草素B;化合物3和4为首次从该植物中分离得到。
Objective To study the chemical constituents in the aerial parts of Hypericum sampsonii.Methods Chromatographic methods were used for the isolation and purification.The structures were identified on the basis of spectroscopic analysis.ResultsFour compounds were isolated from the 60% ethanol extract in the aerial parts of H.sampsonii.They were identified as 3′,5′-dihydroxy-2,4,6-trimethoxylbenzophenone（1）,3′-hydroxy-2,4,6-trimethoxylbenzophenone-5′-O-α-L-rhamnopyranoside（2）,2-hydroxy-4,6-dimethoxylbenzophenone（3）,and 2,4,6,3′,5′-pentamethoxylbenzophenone（4）.Conclusion Compounds 1 and 2 are two new benzophenone compounds named sampsine A and sampsine B; Compounds 3 and 4 are isolated from H.sampsonii for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2015年第5期625-628,共4页
Chinese Traditional and Herbal Drugs
基金
中国科学院上海药物研究所新药研究国家重点实验室开放研究基金(编号SIMM1203KF-09)
