摘要
目的:观察黄精赞育方加味联合前列通瘀胶囊治疗不育患者精浆抗精子抗体异常的临床效果。方法:将263例患者随机分为2组,中药联合组148例采用黄精赞育方加味联合前列通瘀胶囊治疗,对照组115例采用强的松小剂量持续疗法,疗程均为3月。观察2组治疗前后精浆抗精子抗体、精子密度及活动力的改变。结果:精浆抗精子抗体转阴疗效:有效率中药联合组为91.21%,对照组为69.57%,2组比较,差异有非常显著性学意义(P<0.01)。治疗后中药联合组精子密度、活动力较治疗前显著改善(P<0.05);与对照组比较,差异也有显著性意义(P<0.05)。对照组精子密度、活动力治疗前后变化不大(P>0.05)。不良反应率中药联合组为2.70%,对照组为15.65%,2组比较,差异有显著性意义(P<0.05)。结论:黄精赞育方加味联合前列通瘀胶囊治疗不育患者精浆抗精子抗体异常临床效果显著,副作用小。
Objective： To observe the clinical effect of Huangjing Zanyu Decoction combined with Qianlie Tongyu capsules in the treatment of male infertility with antisperm antibody postitive. Methods： Two hundreds and sixty-three qualified patients were randomly divided into two groups, combination group having 148 cases treated with HuangjingZanyu decoction combined with Qianlie Tongyu capsules, and control group having 115 cases receiving perennial treatment with low-dose prednisone. The course of treatment covered 3 months. Antisperm antibody, sperm density and sperm activity of each group were observed. Results： Negative rate of seminal plasma antisperm antibody was 91.21% in combination group, and was 69.57% in the control group, the difference being significant（P 〈 0.01）. Sperm density and sperm activity in the combination group was improved after treatment（P 〈 0.05 compared with those before treatment）, while little change happened in the control group had. The difference between the two groups after treatment was significant（P 〈 0.05）. The incidence of adverse reaction in the combination group was 2.70%, and was 15.65% in the control group, the difference being significant（P 〈 0.05）. Conclusion： Huangjing Zanyu decoction combined with Qianlie Tongyu capsule for male infertility with antisperm antibody positive has significant clinical effect, but has mild side effect.
出处
《新中医》
CAS
2015年第1期96-98,共3页
New Chinese Medicine
关键词
抗精子抗体异常
精浆
黄精赞育方
前列通瘀胶囊
不育
Antisperm antibody positive
Seminal plasma
Huan^ing Zanyu decoction
Qianlie Tongyu capsule
Infertility
