摘要
中药材质量控制在中药临床应用和实践中起着重要的作用,但目前通过对单一或某几个成分的含量控制,不足以反映药材的内在质量,因此提升中药材质量控制标准对中药材品质评价、栽培种植及深加工产品研究均具有深远的意义。本文在现有的中药材质量控制研究方法基础上,提出"谱效关系+一测多评"的研究思路,即将谱效关系与一测多评相结合,首先利用谱效关系寻找到与药材主要疗效相关的化学成分,然后通过液相色谱/电喷雾多级质谱联用技术/柱色谱等确定这些化学成分的结构,最后利用一测多评的方法对所寻找到的化学成分进行全面评价,以全面提升中药材的质量控制标准,达到"深入研究,浅出标准"的目的,为中药材质量控制研究提供研究方法和新思路,从而推动中药材国际化。
The quality control of Chinese herbs plays important roles in clinical application and practice. At present, it is insufficient to indicate the quality control of Chinese herbs by determination of single-component or a few components. Therefore, improving the standard of quality control of Chinese herbs is of great significance to evaluation, planting and deep processing of Chinese herbs. Based on the current approach of quality control of Chinese herbal medicine, we put forward the research idea that combines the spectrum effect relationships with the multi-components quantities by one marker to improve overall quality control standard of Chinese herbal medicine. First of all, we must elucidate the chemical composition that is related to curative effects through spectrum. Second, their structures were determined by HPLC, LC-ESI-MSn, and column chromatograph. Finally, the quality of medicinal materials was appraised through the multi-components quantities by one marker. It has been used to provide a research method of quality control of medicinal materials and promote internationalization of Chinese herbal medicine.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第19期225-228,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
"十一五"国家科技支撑计划项目(2011BAI05B05
2011BAI05B01)
关键词
中药材
质量控制标准
指纹图谱
谱效关系
一测多评
Chinese herbs medicine
quality control standards
fingerprint
spectrum effectrelationships
multi -components quantities by one marker
