摘要
目的 探讨新斯的明硬膜外腔注入用于手术后镇痛的剂量依赖性。方法 6 0例子宫肌瘤切除术或卵巢肿瘤切除术的患者随机分为六组 ,每组 10例 ,于硬膜外麻醉手术结束时硬膜外腔分别注入新斯的明 0 5、1、2或 3mg ,每组均加东莨菪碱 0 3mg和布比卡因 0 15mg。测定术后镇痛时间与镇痛强度 ,并与生理盐水组和 0 15mg布比卡因组作比较。 结果 新斯的明 0 5mg组镇痛时间与镇痛强度不如 1mg组 (P <0 0 5 ) ,2mg组和 3mg组镇痛时间与镇痛强度与 1mg组无明显差异(P >0 0 5 ) ,生理盐水对照组与布比卡因对照组则无镇痛作用。结论 硬膜外腔注入新斯的明、东莨菪碱、布比卡因混合液 。
Objective To compare the efficacy of different doses of neostigmine used for epidual postoperative analgesia.Methods 60 patients(n=10) undergoing hystero-mymetomia and oophoroeystectomy were randomly allocated to one of six groups according to the drug used.The patients receiving epidural neostigmine 0.5,1,2 or 3mg plus scopolamine 0.3mg and bupivacain 0.15mg were compared with those receiving saline (NS or bupivacain 0.15mg only as the control groups).The visual analog scale (VAS) was used to evaluate the efficacy of analgesia.Results The postoperative analgesia time and intensity of neostigmine 0.5mg group was not as good as those of 1mg group (P<0.05).The analgesic effect of 2mg group and 3mg group was as good as that of 1mg group (P>0.05).Conclusion Epidural neostigmine 1,2,or 3mg plus scopolamine 0.3mg and bupivacain 0.15mg produced a dose-independent analgesic effect.
出处
《临床麻醉学杂志》
CAS
CSCD
2002年第4期191-192,共2页
Journal of Clinical Anesthesiology
