摘要
目的对他汀类药物在缺血性卒中及短暂性脑缺血发作二级预防中的作用进行评价分析,为今后的临床预防以及合理用药工作提供可靠的参考依据。方法 抽取在2010年1月至2012年12月间本院收治的缺血性卒中/短暂性脑缺血发作患者218例,将其按照病情程度分成高危组、极高危Ⅱ组、极高危Ⅰ组,对这三组患者入院后与随访3个月的临床用药情况进行统计分析。结果本组218例患者中在住院期间预防性应用他汀类药物者115例,应用率为52.75%,其中极高危Ⅰ组他汀类药物应用与指南的符合率较高危组与极高危Ⅱ组高(P<0.05);随访3个月后,他汀类药物应用者为49例,应用率为22.48%,较住院期间发生显著降低(P<0.05)。结论在预防缺血性脑卒中和短暂性脑缺血发作时他汀类药物发挥了重要作用,降低了复发率,然其二级预防中用药依从性较差,与应用指南符合率较低,临床应予以注意,做好预防工作,合理用药,以改善患者预后。
Objective To statins Episode two level prevention in ischemic stroke and transient ische-mic evaluation and analysis,provide a reliable basis for the clinical prevention and rational administration in the future. Methods From Jan. 2010 to Dec. 2012. in ischemic stroke and transient ischemic attack patients ad-mitted to our hospital 218 cases,according to the severity of disease into high risk group,high risk group,high risk group,the three groups of patients after admission and 3 months of follow-up clinical situation analysis. Re-sults of 115 cases of the 218 patients in the hospital preventive use of statins,application rate was 52. 75% ,among the high-risk group of statins application in accordance with the guidelines of high risk group and high risk group II high （P〈0.05） ; after 3 months of follow-up,statin drugs should be used in 49 cases,the appli-cation rate of 22. 48% ,significantly lower than during hospitalization （P〈0.05） . Conclusion Statins in the prevention of ischemic stroke and transient ischemic attack drugs play an important role,reduces the recurrence rate,but the secondary prevention medication compliance is poor,and application guide for the coincidence rate is low,clinical attention should be,do good precaution work,rational drug use,to improve the prognosis of the patients.
出处
《中国实用医药》
2013年第18期1-3,共3页
China Practical Medicine
关键词
他汀类药物
缺血性卒中
短暂性脑缺血发作
二级预防
临床应用
Statins
Ischemic stroke
Transient ischemic attack
Two levels of prevention
Clinical application
