摘要
目的探讨分析中高频下降型突发性聋患者药物治疗的疗效。方法采用国际通用的标准化临床研究方法进行前瞻性临床多中心研究，收集年龄18～65周岁，病程在2周以内，未经任何相炎医疗处理的中高频下降型突发性聋病例（纯音测听2000Hz以上频率听力下降15dBHL以上），根据统一设计的随机表，随机选取四种治疗方案巾的一种进行治疗，并对疗效进行统计分析。结果141例中高频下降型突发性聋患者，随机选取治疗方案，利多卡因组20例，利多卡因＋糖皮质激素组21例，银杏叶提取物（金纳多）组40例，金纳多＋糖皮质激素组60例。治疗1个月后随访，耳聋痊愈42例（29．79％），显效24例（17．02％），有效27例（19．15％），无效48例（34．04％），总有效率为65．96％。各治疗方案组的总有效率分别为：利多卡冈组55．00％，利多卡因＋激素组66．67％，金纳多组67．50％，金纳多＋激素组68．33％，组间比较，差异无统计学意义（）（。=7．17，／9〉0．05），但治愈率比较，金纳多组明显优于利多卡因组（P=0．0496）。119例伴有耳鸣者，耳鸣改善总有效率为81．5l％，各治疗组的总有效率分别是利多卡因组57．89％（11／19），利多卡冈＋激素组100．00％（18／18），金纳多组88．57％（31／35），金纳多＋激素组78．72％（37／47）；组问两两比较，利多卡因＋激素组耳呜疗效优于利多卡因组（P=0．002）和金纳多＋激素组（P=0．029），利多卡因组和金纳多组问差异亦具有统计学意义（X2=6．705，P〈0．05）。43例伴耳闷者，治疗总有效率90．70％，各组问有效率比较差异无统计学意义（X2=5．97，P=0．74）。17例伴头晕或眩晕者及10例伴有其他不适症状者，治疗后症状改善总有效率均为100．00％。结论对于中高频下降型突发性聋患者，四种药物治疗方案均有效，�
Objective To analyze the therapeutic effect of treatment for intermediate and high- frequency sudden sensorineural bearing loss （SSNHL）. Methods A prospective clinical multicentre research was conducted using international standardized approach of clinical research. SSNHL Cases with intermediate and high-frequency hearing loss, that accepted no medicationfrom onset of hearing loss withintwo weeks duration and ages ranged between 18 and 65, were collected. All patients were treated byone of four treatments plans chosen by unified random table. Results 141 patients with intermediate and high-frequency SSNHL were recruited in the research. Twenty subjects were treated with lidocaine, 21 cases with lidocaine and hormone, 40 cases with Ginaton, and 60 cases with Ginaton and hormone. 42 out of 141 （29.79%） patients were total recovery, 24 （17.02%）achieved excellent recovery, 27 （19.15%）achieved partial recovery, and 48 （34.04%） were ineffective. The total effective rate was 65.96%. In lidocaine group, the total effective rate was 55.00% , 66.67% in lidocaine and hormone group, 67.50% in Ginaton group, and 68. 33% in Ginaton and hormone group. Considering the total effective rate, there was no statistical difference between four groups （ P 〉 0.05 ）. However, the recovery rate in Ginaton group was significant difference comparing with that in lidocaine group （ P = 0. 0496）. 119 had concomitant symptom of tinnitus, and the tinnitus was improved in patients of 81.51%. With regard to total effective rate of tinnitus in four treatment groups, it was 57.89% （11/19） in lidocaiue group, 100.00% （18/18） in lidoeaine and hormone group, 88.57% （31/35） in Ginaton group, 78.72% （37/47） in Ginaton and hormone group. There was significant ascendency in lidoeaine and hormone group versus that in lidoeaine group （ P = 0. 002） and Ginaton and hormone group （ P = 0. 029 ）. And the difference between lidoeaine and Giuaton groups was statistical significance （ X2 = 6. 705, P 〈 0.05�
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2013年第5期368-373,共6页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词
听觉丧失
突发性
测听法
纯音
随机对照试验
药物疗法
Hearing loss, sudden
Audiometry, pure-tone
Randomized controlled trial
Drug therapy
