摘要
目的:探索无创正压通气(non-invasive positive pressure ventilation,NIPPV)在老年慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)合并呼吸衰竭中的作用。方法:回顾性分析,我院2008年12月至2010年12月收治的60例老年AECOPD合并呼吸衰竭患者的临床资料。根据治疗方法不同,分为面(鼻)罩双水平正压通气(BiPAP)治疗组(26例)和常规治疗组(34例)。比较两组动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、pH值、插管率及病死率。结果:与常规治疗组相比,BiPAP治疗组插管率和病死率较低。与治疗前相比,治疗1～2 h、72 h后及出院前BiPAP治疗组患者PaO2、pH值升高,PaCO2降低,差异有统计学意义。结论:NIPPV能缓解呼吸肌疲劳,合理应用BiPAP治疗可明显改善PaO2、PaCO2及pH值等生理学参数,减少气管插管率,降低病死率,对治疗老年AECOPD合并呼吸衰竭有一定临床意义。
Objective：To explore the non-invasive positive pressure ventilation（NIPPV） in acute exacerbation of elderly patients with chronic obstructive pulmonary disease（AECOPD） with respiratory failure.Methods： A retrospective analysis of 60 cases admitted in December 2008-2010 December elderly AECOPD complicated by respiratory failure in patients with clinical data.According to the different treatment methods,divided into the face（nose） mask bi-level positive pressure ventilation（BiPAP） treatment group（26 cases） and the conventional treatment group（34 cases）.Were compared between the two groups,arterial partial pressure of oxygen（PaO2）,partial pressure of carbon dioxide in artery（PaCO2）,pH value,intubation rate,mortality.Results： Compared with the conventional treatment group,BiPAP treatment group intubation rate and low mortality.Compared with before treatment,treatment after 1~2 hours,72 hours and prior to discharge of BiPAP treatment group,PaO2,pH values increased.PaCO2 was lower,the difference was statistically significant.Conclusion： NIPPV can ease breathing machine fatigue,reasonable application of BiPAP therapy can significantly improve,PaO2,PaCO2,pH value and other physiologic parameters,reducing the rate of endotracheal intubation and reduce mortality,the treatment of elderly AECOPD complicated by respiratory failure of some clinical significance.
出处
《心肺血管病杂志》
CAS
2012年第6期687-689,共3页
Journal of Cardiovascular and Pulmonary Diseases
关键词
无创正压通气
慢性阻塞性肺疾病急性加重期
呼吸衰竭
Non-invasive positive pressure ventilation
Acute exacerbation of chronic obstructive pulmonary disease
Respiratory failure
