摘要
目的探讨高同型半胱氨酸血症(HHcy)与复发性脑梗死(RCI)的关系,为缺血性脑血管病的二级预防开辟新的预防和治疗途径。方法将90例急性脑梗死患者,分为首发性脑梗死组(FCI组)46例,复发性脑梗死组(RCI组)44例,测定空腹血浆同型半胱氨酸(tHcy)水平,并与40例健康者(对照组)对照研究。结果空腹血浆tHcy水平RCI组为(23.96±6.07)μmol/L,FCI组(21.61±4.72)μmol/L,两组比较差别有统计学意(P<0.05)。FCI组中HHcy 18例,发生率39.13%;RCI组中HHcy 21例,发生率47.72%,正常对照组HHcy 2例,发生率5%。RCI组HHcy的检出率显著高于FCI组,且2者检出率均显著高于对照组(均P<0.05)。空腹血浆tHcy水平与RCI具有显著相关性,而与高血压病、血脂异常、糖尿病等RCI可能的危险因素无显著相关性,提示HHcy可能是RCI的一个独立的危险因素。结论 HHcy与RCI关系密切,可能为其一个独立的危险因素。
Objective To study tile relationship between hyperhomocysteinemia （HHcy） and re- current cerebral infarction （RCI）. Methods Eighty patient s with acute cerebral infarction （ACI） were divided into a first crehral infarction （FCI） group （ n = 46） and a RCI group （ n = 44） , and 40 healthy people acted as controlgroup. Results The levels of plasma fasting homoeysteine in the RCI group （23.96±6.07） μmol/L was significantly higher than that in the FCI group （21.61±4.72） μmol/ L （P〈 0.05）. The incidence of HHcy in the RCI group （21/44,47.72M） was significantly higher than that in t he FCI group （18/46,39.13%）, and both of them were higher than the incidence of HHcy in the control group （2/40,5%） （P 〈 0.05）. Conclusions HHey may be an independently risk factor that is associated with RCI.
出处
《齐齐哈尔医学院学报》
2012年第17期2338-2339,共2页
Journal of Qiqihar Medical University
