摘要
目的:探讨化瘀温胆汤对代谢综合征大鼠血压、血脂异常的治疗作用及部分机制。方法:健康雄性SD大鼠高温高湿环境下喂饲高脂高糖高盐饮食12周,复制大鼠代谢综合征模型。通过检测血压、血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),探讨化瘀温胆汤灌胃给药4周后对模型大鼠血压、血脂异常的改善作用。检测脂联素、瘦素、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)变化情况,探讨该方治疗代谢综合征的部分机制。结果:化瘀温胆汤可明显降低模型大鼠的血清TC、TG、LDL-C水平,升高HDL-C,与模型对照组比较有显著性差异(P<0.01);可降低模型大鼠血压,与模型对照组比较有显著性差异(P<0.01)。化瘀温胆汤可使脂联素水平明显升高,与模型对照组比较有显著性差异(P<0.01);瘦素水平、TNF-α、IL-6水平均有不同程度的降低,与模型对照组比较均具有显著性差异(P<0.01)。结论:化瘀温胆汤对代谢综合征模型大鼠血压、血脂异常有较好的疗效,其机制可能与其调节脂联素、瘦素、TNF-α、IL-6水平有关。
Objectives： To observe the therapeutic effects of HuaYu Wendan decoction on abnormal blood pressure and blood lipids of laboratory metabolic syndrome（MS） rats and its partial mechanism.Methods： To render rats by feeding high-lipid,high-glucose,high-salt diet in the high temperature and high humidity environment and then treated them with HuaYu Wendan decoction for four weeks.Then we observed the effects of the decoction on blood pressure,serum cholesterol,triglyceride,low density lipoprotein and high density lipoprotein after four weeks＇ administration.We studied the mechanism through detecting several adipose cell cytokines such as adiponectin,leptin,tumor necrosis factor-alpha（TNF-α） and interleukin 6（IL-6）.Results： Huayu Wendan decoction had functions of decreasing blood pressure,improving hyperlipemia（decreasing TG,TC,LDL-C and increasing HDL-C）.There was a significant difference between the decoction group and model control group（P0.01）.The level of serum adiponectin in the decoction group increased and the level of leptin,TNF-α,IL-6,impairing decreased with the model control group（P0.01）.Conclusions： Huayu Wendan decoction can decrease blood pressure and improve hyperlipemia of MS rats,and the mechanism may be that the decoction influences several important adipose cell cytokines.
出处
《中医药信息》
2011年第6期58-60,共3页
Information on Traditional Chinese Medicine
基金
黑龙江省青年基金项目(QC08C76)
黑龙江省中医药管理局项目(ZHY08-W05)
关键词
代谢综合征
血脂
血压
脂肪细胞因子
化瘀温胆汤
Metabolic syndrome
Blood lipids
Blood pressure
Adipose cell Cytokine
Huayu Wendan decoction
