摘要
目的 探讨中国人群载脂蛋白E（ApoE）基因多态性与脑出血的相关性.方法 通过文献检索收集脑出血组和对照组的病例对照研究,剔除不符合要求的文献,以漏斗图检验人选文献的发表偏倚,并根据各入选文献结果的同质性检验结果进行数据合并,计算总OR值,Meta分析采用Review Manager 4.2版统计软件.结果 共有10篇符合条件的文献纳入分析,Meta分析结果表明,以野生型E3/3基因型为参照,携带E2/2,E2/3,E2/4,E3/4,E4/4基因型的个体发生脑出血的危险性的OR值和95%可信区间分别为1.25（0.61～2.58）、1.35（0.86～2.11）、1.89（1.08～3.29）、1.79（1.44～2.23）和1.97（0.91～4.28）,携带E4的个体OR值和95%可信区间为1.01（1.40～2.22）（P＜0.01）,携带E2的个体OR值和95%可信区间为1.45（0.99～2.14）（P＞0.05）.结论 E4等位基因携带者可能是脑出血的遗传危险因素.
Objective To study the relationship between ApoE polymorphism and susceptibility of intracerebral hemorrhage in Chinese by Meta analysis. Methods The literatures with ApoE polymorphism and intracerebral hemorrhage concerning Chinese population were reviewed. Methods： The literatures were abstracted based on the defined selection criteria by two independent investigators. Publication bias was tested by funnel plot and the odd ratio （ OR ） of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Review Manager （Version 4.2）was used for Meta analysis. Results Ten papers were selected based on the criteria. Meta analysis results showed that the combined OR values（95 % CI ）of intraeerebral hemorrhage for subjects of E2/2, E3/2, E4/2,E4/3 and E4/4 were 1.25（0.61~2.58）,1.35 （0.86~2. 11）,1.89（1.08~3. 29）,1. 79（1.44~ 2.23） and 1.97（0.91~4.28） respectively. The combined OR values（95% CI ） of intracerebral hemorrhage for E4 carriers was 1.01 （1.40 ~ 2.22 ） （P 〈 0.01 ）. The combined OR values（95 % CI ） of intraeerebral hemorrhage for E2 carriers was 1.45（0.99~2. 14） （P 〉 0.05）. Conclusions The results suggested that ApoE polymorphism was significantly associated with susceptibility of intracerehral hemorrhage. E4 carriers had higher risk for Chinese to suffer from intraeerebral hemorrhage than other ApoE polymorphism carriers.
出处
《神经疾病与精神卫生》
2011年第1期22-25,共4页
Journal of Neuroscience and Mental Health
