摘要
目的:利用近红外光谱技术建立一种无损快速鉴别头孢类原料药的方法。方法:不破坏样品包装,用光纤探头直接采集8种头孢类原料药的近红外漫反射光谱,采用化学计量学方法对光谱进行预处理,剔除异常光谱,建立头孢类药物的近红外识别模型,并进行模型验证。结果:将经一阶导数+矢量归一化法预处理所建立的模型用于识别头孢类药物,其准确性、专属性和耐用性均良好。结论:该方法可实现对头孢类原料药的无损快速鉴别,为头孢类药物的鉴别提供了一条准确、简单、有效的途径。
Objective：To develop a fast and nondestructive method for the identification of cephalosporin APIs.Methods：The NIR diffuse reflectance spectra of 8 kinds of the APIs with complete package were directly collected using a fiber-optic probe and pre-processed by chemometrics to establish a NIR model for identifying the APIs,excluding exceptional spectra.Then,the model validation was conducted.Results：The established model pre-processed by first derivative and vector normalization had good specificity and ruggedness for identifying the APIs.Conclusion：The method is reliable for the fast and nondestructive identification of cephalosporin APIs.It is considered to be an accurate,simple and effective approach for identifying cephalosporins.
出处
《药学进展》
CAS
2011年第1期36-39,共4页
Progress in Pharmaceutical Sciences
关键词
近红外光谱
无损鉴别
头孢原料药
near infrared spectroscopy
nondestructive identification
cephalosporin APIs
