摘要
采用乳化固化法制备了平均粒径为820nm海藻酸钙微球,并制备了海藻酸钙/几丁聚糖微胶囊。以牛血清白蛋白(BSA)为模型药物,考察投药浓度、几丁聚糖分子量和浓度等对微胶囊载药量和药物释放的影响,发现其载药量最大可达40%以上,结果还显示这种微胶囊具有很好的体外缓释性能。
Calcium alginate microspheres with mean diameter of 820 nm and calcium alginate/chitosan microcapsules were prepared by emulsion-curing.Effects of drug concentration,the molecular weight and concentration of chitosan on drug-loading and drug-release of the microcapsules were investigated using bovine serum albumin（BSA）as a model drug.The maximum drug-loading was over 40%,and the microcapsules also showed good property of sustained-release in vitro.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2010年第9期1725-1729,共5页
Chemical Industry and Engineering Progress
基金
国家863计划(2006AA02A118)
国家自然科学基金(30370415)
福建省自然科学基金(2009J01253)资助项目
