摘要
目的:用相分离方法制备得到肠溶微囊并且探讨其包封率,载药量和体外释放情况。方法:先将牛血清白蛋白从溶液中盐析出来,然后用磷酸调节pH至酸性将肠溶材料沉淀的相分离方法而制备得到微囊。并根据标准曲线测定其包封率,载药量,体外释放程度。结果:微囊的成型的最优化条件为:沉淀pH为1.0,EudragitL30D-55的沉淀质量浓度为0.02μg.mL-1,BSA与EudragitL30D-55的比例为1∶100。在最优化的条件下,微囊的包封率可以达到100.2%,载药量达到4.9%。结论:用EudragitL30D-55做为肠溶材料完全可以做到肠溶效果。
OBJECTIVE To prepare enteric microcapsules by using phase separation and explore its encapsulation efficiency, the drug loading and in vitro release. METHODS Bovining serum albumin and enteric material fractionation method of separation and preparation to be rnicroencapsulated. According to the standard curve and the determination of its encapsulation efficiency, the drug loading and release in vitro level. RESULTS After testing, the microcapsules forming the most optimal conditions ： pH 1.0 precipitation, Eudragit L30D-55 concentration of the sediments 0. 02 μg·mL^-1, BSA and Eudragit L30D-55 of the ratio of 1 ： 100. In the most optimal conditions, the microcapsules encapsulation efficiency could be achieved 100. 17%, the drug amounted to 4. 92%. CONCLUSION Eudragit L30D-55 as enteric material could do enteric effect.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2010年第13期1117-1120,共4页
Chinese Journal of Hospital Pharmacy
关键词
肠溶微囊
牛血清白蛋白
相分离法
正交试验设计
药物释放廛
enteric-coated microcapsules
bovine serum albumin
fractionation method of separation
orthogonal experimental design
drug realease
