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CYP2A6基因多态性与食管癌易感性的关系

Relationship between CYP2A6 gene polymorphism and susceptibility of esophageal cancer
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摘要 目的:研究CYP2A6基因rs8192720多态性与新疆汉族食管癌易感性的关系。方法:采用病例-对照研究方法,以聚合酶链式反应-连接酶检测反应(polymerase chain reaction-ligase detection reaction,PCR-LDR)技术,分析107例食管癌患者(病例组)和204例非食管癌患者(对照组)CYP2A6基因rs8192720A/G位点基因型的分布,并比较不同基因型与食管癌易感性的关系。结果:GG、GA、AA基因型在病例组中的分布频率分别为66.35%、32.69%和0.96%,在对照组中为69.59%、27.84%和2.58%,两组间基因型频率分布差异无统计学意义(χ2=1.45,P=0.48);GG和GA+AA基因型在病例组和对照组中分布差异也无统计学意义(χ2=0.33,P=0.57)。结论:CYP2A6基因rs8192720A/G位点多态性与新疆地区汉族人食管癌易感性无相关性。 Objective: To determine the association between cytochrome P450 2A6 rs8192720 polymorphism and the susceptibility of esophageal cancer in Han nationality. Methods: A case-control study was conducted. The polymorphism of CYP2A6 gene at rs8192720 A/G position was analyzed by polymerase chain reaction-ligase detection reaction (PCR-LDR) methods in 107 esophageal cancer cases and 204 non-cancer controls. The frequencies of genotype and allele and the association between the genetic polymorphisms and cancer risk were analyzed. Results: The frequency of GG, GA and AA genotypes in the case subjects were 66.35%, 32.69%, 0.96% respectively and in the control subjects were 69.59%, 27.84%, 2.58%. No significant difference was observed in the frequency of CYP2A6 genotypes between cases and controls (X^2 =1.45, P =0.48). The genotype of GG and GA+AA has not significance between the cases and controls (X^2=0.33, P =0.57). Conclusion: CYp2A6 rs8192720A/G polymorphism is unlikely to be associated with the susceptibility to esophageal cancer.
出处 《新疆医科大学学报》 CAS 2009年第5期536-538,542,共4页 Journal of Xinjiang Medical University
基金 国家自然科学基金资助项目(30460118) 新疆地方病分子生物学重点实验室开放课题项目(XJD0208-2006-05)
关键词 CYP2A6 食管癌 遗传易感性 基因多态性 CYP2A6 esophageal cancer susceptibility genetic polymorphism
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