摘要
目的:探讨多烯紫杉醇及顺铂联合腹腔化疗治疗进展期胃癌的疗效.方法:对45例进展期胃癌患者进行多烯紫杉醇及顺铂联合腹腔化疗,比较腹腔化疗前后两组肿瘤体积大小、血常规、肝肾功的变化,观察腹腔化疗术后的不良反应,并对所有患者进行随访观察其生存时间.结果:腹腔化疗后胃癌体积明显缩小(72.4±22.4cm3vs7.23±2.4cm3,t=2.946,P<0.01),患者中位生存期为14.0±1.4mo,对癌性腹水近期有效率为59%.腹腔化疗对患者血常规、肝肾功能中部分指标有一定影响,主要不良反应为脱发、口腔炎、便秘及血尿.结论:多烯紫杉醇及顺铂联合腹腔化疗治疗胃癌疗效好,能明显缩小肿瘤体积,延长患者生存期,减少癌性腹水,且操作方便,不良反应少.
Abstract AIM： To investigate the therapeutic efficacy of peritoneal chemotherapy in combination with tocetaxel and cisplatin for advanced gastric cancer. METHODS： Forty-five cases of advanced gastric cancer were treated with tocetaxel in combina- tion with cisplatin by peritoneal chemotherapy. The tumor size, blood routine examination, he- patic and renal function were compared before and after peritoneal chemotherapy. The side ef- fects were observed. All patients were followed- up and their survival time was recorded. RESULTS： The tumor sizes of gastric cancer were decreased dramatically （72.4 ± 22.4 cm3 vs 7.23 ± 2.4 cm3, t = 2.946, P 〈 0.01）. The average survival time was 14.0 ± 1.4 months, and the short-term therapeutic efficacy was 59%. The peritoneal chemotherapy affected some indexes in blood routine examination, hepatic and renal function. The main side effects included hair loss, stomatitis, constipation and blood urine. CONCLUSION： Peritoneal chemotherapy in combination with tocetaxel and cisplatin reduces the tumor size effectively, prolongs the survival period, and alleviates the tumor ascites in patients with advanced gastric cancer. It＇s convenient and safe for advanced gastric cancer treatment.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第20期2304-2307,共4页
World Chinese Journal of Digestology
关键词
腹腔化疗
胃癌
多烯紫杉醇
Peritoneal chemotherapy
Gastric cancer
Tocetaxel
