摘要
目的探讨血浆组织因子(tissue factor,TF)水平与冠心病的相关性。方法对237例疑诊为冠心病的患者进行冠状动脉造影,按结果分为冠心病组(n=149)和正常对照组(n=88)进行病例对照研究。所有入选对象检测血脂、血糖、血尿酸、超敏C反应蛋白、纤维蛋白原以及血浆TF的水平。采用spearman等级相关、pearson积差相关和Logistic多元回归等方法,分析血浆TF水平和冠心病的相关性,以及TF水平与冠心病其他危险因素的关系。结果冠心病组血浆TF较对照组明显升高(P<0.01);2组内男性和女性差异均无统计学意义(P>0.05);有糖尿病亚组和无糖尿病亚组的差异均有统计学意义(P<0.05)。血浆TF水平与冠心病呈正相关(r=0.791,P<0.001),与糖尿病、低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)[Lp(a)]、超敏C反应蛋白(Hs-CRP)、纤维蛋白原(FIB)均呈正相关(分别r=0.172,0.180,0.147,0.380,0.175;P均<0.05)。Logistic多元回归分析显示,排除年龄、LDL-C、糖尿病,高血压、吸烟等因素影响,血浆TF水平仍与冠心病发生存在有意义的回归关系。结论血浆TF升高可能是冠心病的重要危险因素之一,高水平的TF诱导血栓形成,促进冠心病的发生发展,也是冠心病患者预后的预测指标之一。
Objective To study the relationship between plasma tissue factor and coronary heart disease. Methods 237 patients suspected of coronary heart disease（CHD） were divided into two groups according to the result of coronary angiography： CHD group（ n = 149）and control group（ n = 88）. The total cholesterol, triglycerides, low density lipoprotein cholesterol, high density lipoprotein cholesterol, blood sugar, serum uric acid, high sensitivity C - reactive protein, fibrinogen and plasma tissue factor were determined in all the patients. After the influence of other risk factors were controlled, the relationship between plasma tissue factor with CHD and other risk factors of CHD was analyzed by linear correlation and multiple stepwise regression. Results The level of plasma tissue factor in CHD group was significantly higher than that of control group（ P 〈 0.01）. The difference of plasma tissue factor between man and women subgroup was not significantly in both CHD group and control group（ P 〉 0.05 ）, but in that diabetes and non - diabetes subgroup, the difference was significantly（ P 〈 0.05）. There was a positve correlation between plasma tissue factor with the occurrence of CHD（ r = 0. 791, P〈0. 001）. And plasma tfssue factor correlated with diabetes, LDL - C, Lp（a） Hs - CRP,FIB（respectively r was 0. 172, 0. 180, 0. 147, 0. 380i 0. 175. all P 〈 0.05）. Excluding the influence of age, LDL- C, blood pressure, blood glucose, smoking, etc, multivariate stepwise regression analysis showed that TF was a significant variable associated with the occurrence of CHD. Conclusion High tissue factor level may be one of the important risk factors for CHD. Elevated tissue factor can induce thrombogenesis, enhance the onset and development of CHD. It is also a prognostic factor for patients with CHD.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2007年第6期727-728,共2页
Chinese Journal of Public Health
关键词
冠心病
组织因子
危险因素
coronary heart disease
tissue factor
risk factor
