摘要
采用日本刺参(Apostichopus japonicus)匀浆灌胃移植性肿瘤模型小鼠,探讨了日本刺参的抗肿瘤作用及其对免疫功能的调节作用。结果表明,日本刺参各剂量组均能显著抑制小鼠S180肉瘤的生长,提高小鼠脾指数及胸腺指数(P<0.05);显著提高荷瘤小鼠血清溶血素含量(P<0.01)和抗体形成细胞数(P<0.05);提高迟发型变态反应水平和脾淋巴细胞转化能力(P<0.05,P<0.01);促进NK细胞活性和巨噬细胞的吞噬能力(P<0.05,P<0.01)。提示日本刺参能全面调节机体的特异性和非特异性免疫功能,控制和杀灭肿瘤细胞。
The effects of postichopus japonicus on antitumor and immune regulation in transplanted tumorbearing mice were investigated by oral administration. The results showed that Apostichopus japonicus could inhibit tumor growth in S180 bearing mice remarkably, enhance spleen and thymus indexes, increase the hemolysin content （ P 〈 0.0l） and quantity of antibody-forming cells in vivo （ P 〈 0.05）, heighten the delayed hypersensitivity level and spleen lymphocyte transformation （P 〈 0.05, P 〈 0.01 ）, promote NK cell activity and the phagocytosis ability of celiac macrophage （ P 〈 0.05, P 〈 0.01）. It is suggested that Apostichopus japonicus can restrain and kill tumor cells by regulating both specific and non-specific immune functions.
出处
《中国海洋大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第1期93-96,102,共5页
Periodical of Ocean University of China
基金
新世纪优秀人才支持计划项目(NCET-04-0642)
国家自然科学基金项目(30471319)资助
关键词
日本刺参
抗肿瘤
免疫调节
Apostichopusjaponicus
antitumor
immune function
