摘要
研究了氟喹诺酮新药司帕沙星对实验性感染大肠杆菌-败血霉形体病鸡的疗效。采用试管液体二倍稀释法测得司帕沙星对大肠杆菌(O78)和禽败血霉形体(PG31)的最小抑菌浓度均为0.00625mg·L-1。240只30日龄雏鸡随机分为司帕沙星3个不同剂量组(25,50,100mg·L-1)、环丙沙星对照组(50mg·L-1)、恩诺沙星对照组(50mg·L-1)、泰乐菌素对照组(500mg·L-1)、健康对照组和感染对照组,每组30只鸡,连续饮水给药5d,对实验性感染大肠杆菌-禽败血霉形体病鸡进行治疗试验。结果表明:司帕沙星3个不同剂量组、环丙沙星组、恩诺沙星组、泰乐菌素组的治愈率分别为86.7%、96.7%、96.7%、96.7%、96.7、80.0%,而感染对照组的死亡率为26.7%;司帕沙星及其他对照药物的增重率显著高于感染对照组,且可显著减少气囊损伤率、抗体阳性反应率和病原再分离率,司帕沙星的效果好于或相当于环丙沙星、恩诺沙星,明显好于泰乐菌素。
Pharmacodynamics of a new fluoroquinolones antibacterial sparfloxacin against artificially infected Escherichia Coli and Mycoplasma gallisepticu in chichens was studied. Minimal inhibitory concentrations (MICs) of sparfloxacin against O78 and MGPG31 were 0.00625mg·L-1 , which was determined by two-fold dilution assay in vitro. 240 of 30-day-old chickens was used and randomly assigned to 8 groups, including 3 sparfloxacin (25?50?100mg·L-1), a ciprofloxacin groups(50mg·L-1), an enrofloxacin groups(50mg·L-1), a tylosin group (500mg·L-1), a positive and a negative control group. Every group included 30 chicken. Drugs were given to E.coli-MG infected chickens via drinking water for 5 days, The results showed that the curative rate of sparfloxacin(25, 50 and 100mg·L-1), ciprofloxacin (50mg·L-1), enrofloxacin (50mg·L-1) and tylosin (500mg·L-1) were 86.7%?96.7%?96.7%?96.7%?96.7?80.0% respectively. The mortality of the infected and untreated group was 26.7%. Sparfloxacin was equivalent or superior to ciprofloxacin and enrofloxacin, and significantly superior to tylosin in controlling infection, increasing curing rate, effective rate and weight gain, lowing mortality, positive antibody rate, air-sac damage rate and frequency of pathogenic microorganism isolation.
出处
《沈阳农业大学学报》
CAS
CSCD
2004年第3期231-234,共4页
Journal of Shenyang Agricultural University
基金
辽宁省教育厅高等学校科学研究计划资助项目(202053102)
