摘要
利用国内外一致公认的与衰老有关的4项指标SOD,LPO,MAO,HYP来观察石斛和五味子这2味中药对新西兰家兔(36～42月)的抗衰作用。结果表明:石斛、五味子煎剂浓缩液分别灌胃新西兰兔4周后,石斛组和五味子组的SOD含量均较用药前显著增高(P<0.001)石斛组LPO较用药前显著下降(P<0.02),MAO值亦较用药前下降,并有非常显著的差异(P<0.001),五味子组的LPO、MAO两者均较用药前显著性下降(P<0.001)。另外,石斛组能显著提高血清HYP水平(P<0.002),而五味子组则无明显的影响。对照组饲养1月后,SOD,HYP呈下降趋势,LPO,MAO呈上升趋势,但除LPO有显著性增高(P<0.001)其余均无显著差异(P>0.05)。再者,在增加体重方面.用药1月后,石斛组平均增加0.16kg、五味子组基本不变,而对照组饲养前后体重减轻0.64kg。实验结果表明:石斛,五味子均有抗衰老作用,而石斛的抗衰作用范围较五味子更广泛,更全面。
The four generally recognized senile—indices,SOD,LPO,MAO and HYP were used to study the anti—senility effect of Herba Dendrobii and Fructus Schisandrae on the New Zealand rab- bits (36—42 months).The results showed that decoction concentrates of Dendrobium and Schisandra were injected into the rabbits' stomach rcspectively.4 weeks after injection,the SOD contents in both Dendrobium Group(G1) and Schisandra Group(G2) were remarkably increased,compared with that before treatment(P<0.001).The LPO and MAO in G1 were reduced and remarkably reduced(P<0. 02;P<0.001).Both LOP and MAO in G2 were remarkably reduced (p<0.001).Mo(?)eover,the HYD level in G1 significantly raised(p<0.002)but that in G2 did not change.In the control group,after fed for one month,there was a desending tendency in SOD and HYP,anO an asending tendency in LPO and MAO,but only the change in LPO was significant(p<0.001).After one month,the body—weight of G1 increased on the average of 0.16kg,of G2 was basicly constant but of control group reduced for 0. 64kg.The results of the study indicate that both Dendrobium and Schisandra have the effect of anti— senility,the effect range of Dentrobium is wider and more comprehensive than that of Schisandra.
出处
《福建中医学院学报》
1993年第4期221-223,共3页
Journal of Fujian College of Traditional Chinese Medicine
关键词
石斛
药理学
五味子
衰老
体重
Herba Dendrobii/pharm
Fructus Schisandrae/pharm
senility/drug eff
weight/drug eff.
