摘要
采用G CSF动员的骨髓以及外周血造血干细胞移植治疗重型再生障碍性贫血 (SAA)。共有 10例重型再生障碍性贫血患者接受了G CSF动员的骨髓以及外周血造血干细胞移植 ,回顾性分析植入情况、植入速度及急慢性移植物抗宿主病 (GVHD)发生率等。所有患者移植后均获得造血重建。中性粒细胞计数 (ANC) >0 5× 10 9L- 1 的中位时间为 13 2d(8～ 18) ,血小板 >2 0× 10 9L- 1 的中位时间为 2 2 2d(10～ 10 8)。 8例获得异体植入的患者中 3例发生Ⅰ Ⅱ度皮肤急性GVHD ,发生 5例慢性GVHD。至随访截止 ,中位随访 775d(2 10～ 14 2 9) ,所有 10例患者均无病存活(DFS)。因此我们认为G CSF动员的骨髓及外周血干细胞移植是治疗SAA的有效方法 ,可获得快速、持久植入 ,而不增加急性和慢性GVHD的发生率。
To study the feasibility and clinical outcome of transplantation of G-CSF primed bone marrow (G-BM) and G-CSF mobilized peripheral blood stem cells(G-PBSC) in severe aplastic anemia (SAA). This study retrospectively analyzed the outcome of 10 patients with SAA receiving mixed G-BM plus G-PBSC transplantation in our institute, including engraftment, speed of engraftment and the occurrence of acute and chronic graft versus host disease (aGVHD and cGVHD). All patients achieved hematopoietic recovery after transplantation. The median time to attain an absolute neutrophil count above 0.5×10 9 cells/L was 13.2 days (8～18). The median time to attain a platelet count above 20×10 9cells/L was 22.2 days (10～108). Three of eight patients receiving allogeneic stem cells developed grade Ⅰ-Ⅱ aGVHD limited to skin. Five of the evaluable 8 patients developed chronic GVHD. All 10 patients were still alive and event-free with a median follow-up duration of 775 days (range 210～1429 days). These results suggest that the transplantation of G-CSF mobilized allogeneic bone marrow plus peripheral blood stem cells is an effective treatment for SAA. It can provide rapid and sustained engraftment without increase in incidence of aGVHD and cGVHD.
出处
《基础医学与临床》
CSCD
北大核心
2004年第3期291-294,共4页
Basic and Clinical Medicine
