摘要
目的:调查抗菌药物预防性应用对重型病毒性肝炎医院感染的影响,并探讨其应用机制。方法:选择入院前1周未经抗菌治疗、入院时无感染征象、住院时间超过72小时的重型肝炎病例,根据临床分期及抗菌药物应用情况分组、对照研究。结果:159例患者中76例发生医院感染,未预防性应用抗菌药物组(A组)、静脉注射第三代头孢菌素组(B组)及半合成青霉素组(C组)医院感染率分别为56.16%(41/73)、34.01%(17/50)和50.0%(18/36),B组明显低于A组(P<0.05);B组医院感染发生时间较A组明显推迟,B组可降低中期重型肝炎的病死率、与A组比较有显著性差异(16.67% us 50.0%,P<0.05)。结论:早期患者应用预防性抗菌药物可推迟医院感染发生时间,但对降低医院感染率及病死率无统计学意义;中、晚期患者预防性应用第三代头孢菌素对推迟医院感染发生时间、降低医院感染率及病死率是有效的。
Objective: To evaluate the effectiveness of prophylactic antibiotic therapy on nosocomial infection in patients with severe viral hepatitis, and inquiry into its applied mechanism. Methods: 159 cases with severe viral hepatitis were divided into groups according to clinical stage and the applied circumstance of antibiotic medicine; group A: receiving no prophylactic antibiotics therapy, group B intravenous injecting the third generation cephalosporins and group C intravenous injecting the semisymthetic peni...
出处
《中西医结合肝病杂志》
CAS
2003年第S1期10-14,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
泉州市科技计划项目课题(No.Z9606
Z200224)
关键词
重型病毒性肝炎
医院感染
预防性抗菌治疗
Severe Viral Hepatitis
Nosocomial Infection
Prophylactic Antibiotic Therapy