摘要
目的:制备优良的丹皮酚混悬剂,为科学研究提供有效的实验材料。方法:通过研磨和涡旋两种分散法制备丹皮酚混悬剂,以沉降容积比和重新分散为质量评价指标。结果:利用阿拉伯胶制备丹皮酚混悬剂,其3h后的沉降容积比为0.98,3次振摇后可以使药物重新分散。结论:以阿拉伯胶作为助悬剂通过研磨法制备的丹皮酚混悬剂,其外观细腻,分散微粒较细小,沉淀容积最大,稳定性最好。
Objective:To produce paeonol suspension and provide effective experimental materials for scientific research.Methods:To produce paeonol suspension by grinding and vortex dispersion;to take the settlement volume ratio and re-dispersion of paeonol suspension as the quality evaluation indicators for the stability of paeonol suspension.Results:The settlement volume ratio of paeonol suspension produced by grinding with Arabic gum is 0.98,and the drug is re-dispersed after 3 times of shaking.Conclusion:Paeonol suspension produced by grinding method with Arabic gum as suspension agent has fine appearance and smaller discrete particles with maximum precipitation capacity and the best stability.
作者
李岩
陈梦菲
张赫彬
李金涛
刘冰雨
苏瑞
LI Yan;CHEN Mengfei;ZHANG Hebin;LI Jintao;LIU Bingyu;SU Rui(Heze Medical College,Heze,274000,China)
出处
《江西化工》
2022年第3期78-80,共3页
Jiangxi Chemical Industry
基金
山东省医药卫生科技发展计划项目(2018WS494)
山东省中医药科技发展计划项目(2019-0320)。
关键词
丹皮酚
助悬剂
稳定性
Paeonol
Suspending agents
Stability
