摘要
目的探讨ICU镇静(咪达唑仑、丙泊酚、右美托咪定)对危重患者谵妄的发生及生命体征的影响,阐明预防危重症患者谵妄发生的合理方案.方法选择90名入住ICU的患者分成3组(A组、B组、C组,每组30人),给予不同镇静方案比较3组患者7 d谵妄发生情况,不同镇静深度下患者的收缩压(SBP)、舒张压(DBP)、心率(HR)的情况.结果 A组患者7 d谵妄发生时间和发生率最高,B组患者7 d谵妄发生时间和发生率次之,C组患者7 d谵妄发生时间和发生率最低(P=0.019),A组对患者生命体征(收缩压、舒张压、心率)影响最少,B组次之,C组最大,但都在正常范围(P=0.001).结论右美托咪定对危重症患者谵妄有预防作用,虽然其有降低患者收缩压、舒张压、心率的副作用,但其在正常范围内,与其他镇静剂相比右美托咪定可以预防危重症患者谵妄.
Objective Explain by studying the impact of ICU sedation the reasonable scheme for the prevention of delirium in critically ill patients （midazolam, propofol, dexmedetomidine） on the incidence of delirium and vital signs in critically ill patients. Methods Chosen 90 ICU patients, which were randomly divided into three groups （A, B and C） and each group had 30 patients. The patients with different sedation depth were treated with different sedation schemes and compared including the occurrence of 7 days delirium, systolic blood pressure （SBP） , diastolic blood pressure （DBP） and heart rate （HR） Results The time and incidence of 7 days delirium of patients in group A were highest, followed by group B, the lowest was group C （P = 0.019） . Vital signs （SBP, DBP and HR） of patients in group A was the least, then was in group B, and then the biggest was in group C, but they were within normal range （P = 0.001） Conclusion Dexmedetomidine has a preventive effect on delirium of critically ill patients, although it has side effects of reducing SBP, DBP and HR of patients, but it is in normal range.
出处
《昆明医科大学学报》
CAS
2015年第9期65-68,共4页
Journal of Kunming Medical University
基金
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2014FA012)
