摘要
目的:对大鼠和人急性口服涕灭威所致乙酰胆碱酯酶(AChE)抑制的无明显不良反应剂量(NOAEL)进行估算,并探讨若饮用美国4个不同地区含有涕灭威残量的地下水而带来的健康影响。方法:采用已构建的大鼠和人的生理药代动力学/药效学(PBPK/PD)模型进行模拟运算。结果:大鼠血液和脑内AChE抑制的NOAEL模拟值分别为0.0169和0.0158 mg/kg(文献报道为0.03和0.06 mg/kg)。模型预测人血和脑AChE抑制的NOAEL值为0.0052和0.0055 mg/kg(文献值为0.01和0.025 mg/kg)。如饮用污染的地下水,所致AChE的抑制对人体不构成显著影响。结论:本模型有助于涕灭威的健康风险评估。
Objective： To estimate the No Observable Adverse Effect Level （NOAEL） in rats and humans and to evaluate the health effects if a normal adult drinks the aldicarb contaminated underground water from four US geographic areas. Methods： The PBPK/ PI） models previously constructed for rats and humans were used for the model simnlatians. Results： Simulations showed the NOAEL value for the AChE inhibition in the blood and brain was 0.0169 and 0. 0158 mg/kg, respectively, for the rat versus the reported 0.03 and 0. 06 mg/kg. Human NOAEL was 0.0052 and 0. 0055 mg/kg, respectively, versus reported 0.01 and 0.025 mg/kg. Model simulation of drinking the underground water showed trace level of AChE inhibition. Conclusion： PBPK/PD modeling is helpful in the risk assessment for aldicarh exposure.
出处
《中国伤残医学》
2014年第7期30-31,共2页
Chinese Journal of Trauma and Disability Medicine
