摘要
双功能手性金属络合物催化的不对称反应是目前有机化学研究的热点之一。本文综述了氮杂半冠醚手性配体与金属有机试剂络合的双金属催化剂,在催化不对称aldol反应、不对称Henry反应、不对称Michael反应、不对称Mannich反应、不对称Friedel-Crafts烷基化反应、不对称炔基化反应、不对称硅氰化反应、共聚反应、去对称化反应以及不对称Nozaki-Hiyama烯丙基化反应体系中的应用进展,重点介绍了不同催化体系对催化剂和反应底物之间立体效应和电子效应的影响,总结了控制反应立体选择性的规律以及有关催化反应的机理。
Bifunctional asymmetric metal-catalysis has attracted a considerable amount attention for organic chemists. This review provides an overview of recent advances on the dinuclear metal catalysts and their applications in asymmetric catalytic reactions, including aldol reaction, Henry reaction, Michael addition reaction, Mannich reaction, Friedel-Crafts alkylation reaction, Nozaki-Hiyama allylation, enantioselective alkynylation, cyanosilylation, desymmetrization and copolymerization, with an emphasis on the clarification of the relationship between either sterical or electronic effects of catalysts and substrates in different catalyst systems, and summarizing the regulation that controls the stereoseleetivity and proposed mechanism of the reaction.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2012年第2期348-360,共13页
Progress in Chemistry
基金
国家自然科学基金项目(No.20972140
20972091
21172139)
河南省教育厅自然科学研究计划项目(No.2011B150029)资助
关键词
手性氮杂半冠醚配体
双金属催化剂
不对称催化
chiral semi-azacrown ether ligand
dinuclear metal catalysts
asymmetric catalysis
