摘要
目的了解参考人群的样品大小对建立骨密度(BMD)参考数据库的影响。方法总样品量是由3662例6～85岁的女性参考人群组成(Tn),将研究对象随机分成1/2n(1831例)、1/4n(916例)和1/8n(458例)共4个组。采用双能X-线吸收法(DXA)骨密度仪,同时测量受试者前后位腰椎、侧位腰椎、髋部和前臂远端的BMD。选择最佳回归模型建立BMD参考曲线和数据库。结果参考人群数量不同的4个样品组建立的各骨骼部位的BMD参考曲线,虽然在腰椎BMD参考曲线的末端存在一些偏差,但4个样品组之间各骨骼部位的全部曲线差异均无显著性,确定的峰值BMD非常相似。采用中国骨质疏松基金会诊断标准,4个样品组建立的BMD参考数据库的骨质疏松检出率差异无显著性。结论本研究揭示了参考人群的样本大小对建立BMD参考曲线和参考数据库的影响,对指导局部地区建立BMD参考数据库确定样本数量具有重要参考价值。
Objective This study attempts to determine a suitable sample size for establishing bone mineral density （BMD） reference databases in a local laboratory. Methods The total reference population consisted of 3662 females aged 6 - 85 years. BMDs were measured with a dual-energy X-ray absorptiometry densitometer. The subjects were randomly divided into 4 different sample groups, total number （Tn） = 3662, 1/2n = 1831, 1/4n = 916, and 1/8n = 458. We used the best regression model to determine BMD reference curve and peak BMD. Results There was no significant difference in the full curves between the 4 sample groups at each skeletal site, although some discrepancy at the end of the curves was observed at the spine. Peak BMDs were very similar in the 4 sample groups. According to the Chinese diagnostic criteria （BMD 〉 25 % below the peak BMD as osteoporosis）, no difference was observed in the osteoporosis detection rate using the reference values determ/ned by the 4 different sample groups. Conclusion Varying the sample size from hundreds to thousands has no decisive effect on establishing BMD reference curve and determining peak BMD. It should be practical for determining the reference population while establishing local BMD databases.
出处
《中国骨质疏松杂志》
CAS
CSCD
2008年第12期859-864,共6页
Chinese Journal of Osteoporosis
关键词
参考人群
样品大小
骨密度
参考数据库
骨质疏松
Reference population
Sample size
Bone mineral density
Reference databases
Osteporosis
